TTTP_BPT4
ID TTTP_BPT4 Reviewed; 176 AA.
AC P13331;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 3.
DT 12-AUG-2020, entry version 79.
DE RecName: Full=Tail tube terminator protein {ECO:0000305};
DE Short=TrP;
DE AltName: Full=Gene product 3;
DE Short=gp3;
DE AltName: Full=Tail sheath-stabilizing protein {ECO:0000305};
DE AltName: Full=Tail-to-head joining protein {ECO:0000305};
DE Short=THJP;
GN Name=3;
OS Enterobacteria phage T4 (Bacteriophage T4).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX NCBI_TaxID=10665;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2644202; DOI=10.1128/jb.171.1.488-497.1989;
RA Lipinska B., Rao A.S.M.K., Bolten B.M., Balakrishnan R., Goldberg E.B.;
RT "Cloning and identification of bacteriophage T4 gene 2 product gp2 and
RT action of gp2 on infecting DNA in vivo.";
RL J. Bacteriol. 171:488-497(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2740234; DOI=10.1093/nar/17.11.4392;
RA Koch T., Lamm N., Rueger W.;
RT "Sequencing, cloning and overexpression of genes of bacteriophage T4
RT between map positions 74.325 and 77.184.";
RL Nucleic Acids Res. 17:4392-4392(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003;
RA Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
RT "Bacteriophage T4 genome.";
RL Microbiol. Mol. Biol. Rev. 67:86-156(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-143.
RX PubMed=4057254; DOI=10.1016/0022-2836(85)90071-3;
RA Broida J., Abelson J.;
RT "Sequence organization and control of transcription in the bacteriophage T4
RT tRNA region.";
RL J. Mol. Biol. 185:545-563(1985).
RN [5]
RP PROTEIN SEQUENCE OF 2-8, AND SUBCELLULAR LOCATION.
RX PubMed=15342608; DOI=10.1128/jb.186.18.6335-6339.2004;
RA Ye N., Nemoto N.;
RT "Processing of the tail lysozyme (gp5) of bacteriophage T4.";
RL J. Bacteriol. 186:6335-6339(2004).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=10633101; DOI=10.1128/jb.182.3.680-688.2000;
RA Vianelli A., Wang G.R., Gingery M., Duda R.L., Eiserling F.A.,
RA Goldberg E.B.;
RT "Bacteriophage T4 self-assembly: localization of gp3 and its role in
RT determining tail length.";
RL J. Bacteriol. 182:680-688(2000).
RN [7]
RP SUBUNIT.
RX PubMed=12591887; DOI=10.1128/jb.185.5.1693-1700.2003;
RA Zhao L., Kanamaru S., Chaidirek C., Arisaka F.;
RT "P15 and P3, the tail completion proteins of bacteriophage T4, both form
RT hexameric rings.";
RL J. Bacteriol. 185:1693-1700(2003).
RN [8]
RP INTERACTION WITH GP15, FUNCTION, AND SUBUNIT.
RX PubMed=23434847; DOI=10.1016/j.jmb.2013.02.012;
RA Fokine A., Zhang Z., Kanamaru S., Bowman V.D., Aksyuk A.A., Arisaka F.,
RA Rao V.B., Rossmann M.G.;
RT "The molecular architecture of the bacteriophage T4 neck.";
RL J. Mol. Biol. 425:1731-1744(2013).
CC -!- FUNCTION: Plays an essential role in tail assembly by capping the
CC rapidly polymerizing tail once it has reached its requisite length and
CC serving as the interaction surface for the completion protein.
CC {ECO:0000269|PubMed:10633101, ECO:0000269|PubMed:23434847}.
CC -!- SUBUNIT: Homohexamer. Interacts with completion protein gp15.
CC {ECO:0000269|PubMed:12591887, ECO:0000269|PubMed:23434847}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:10633101,
CC ECO:0000269|PubMed:15342608}.
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DR EMBL; M23012; AAA50419.1; -; Genomic_DNA.
DR EMBL; AF158101; AAD42439.1; -; Genomic_DNA.
DR EMBL; X03016; CAA26799.1; -; Genomic_DNA.
DR EMBL; X14845; CAA32952.1; -; Genomic_DNA.
DR PIR; C32254; ZRBPT9.
DR RefSeq; NP_049753.1; NC_000866.4.
DR TCDB; 1.K.1.1.1; the gp27/5 t4-baseplate (t4-bp) family.
DR GeneID; 1258776; -.
DR KEGG; vg:1258776; -.
DR Proteomes; UP000009087; Genome.
DR GO; GO:0098015; C:virus tail; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR010667; Phage_T4_Gp19.
DR Pfam; PF06841; Phage_T4_gp19; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Late protein; Reference proteome;
KW Viral tail protein; Virion.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:15342608"
FT CHAIN 2..176
FT /note="Tail tube terminator protein"
FT /id="PRO_0000164995"
FT CONFLICT 57..63
FT /note="GRAQRPG -> ASTTPVV (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 71
FT /note="L -> Q (in Ref. 4; CAA26799)"
FT /evidence="ECO:0000305"
FT CONFLICT 142..143
FT /note="EF -> RI (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="V -> VLMLQFCVL (in Ref. 1; AAA50419)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 176 AA; 19712 MW; 34A0887DBD7D9F7F CRC64;
MSQALQQIFN QANTTNFVVS IPHSNTTSAF TLNAQSVPIP GIRIPVTDTV TGPFGLGRAQ
RPGVTFEYDP LIVRFIVDEE LKSWIGMYEW MLGTSNYLTG ENTAQKTGPE YITLYILDNS
KTEIVMSINF YKPWVSDLSE VEFSYTEDSD PALVCTATIP YTYFQVEKDG KIIAEV
