ID   TTUD3_AGRVI             Reviewed;         385 AA.
AC   P70788;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Putative hydroxypyruvate reductase;
DE            EC=1.1.1.81;
GN   Name=ttuD;
OS   Agrobacterium vitis (Rhizobium vitis).
OG   Plasmid pTrAB3.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
OX   NCBI_TaxID=373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AB3;
RX   PubMed=8672817; DOI=10.1094/mpmi-9-0401;
RA   Salomone J.-Y., Crouzet P., de Ruffray P., Otten L.;
RT   "Characterization and distribution of tartrate utilization genes in the
RT   grapevine pathogen Agrobacterium vitis.";
RL   Mol. Plant Microbe Interact. 9:401-408(1996).
CC   -!- FUNCTION: Degrades an unidentified toxic product from the first step of
CC       tartrate degradation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH;
CC         Xref=Rhea:RHEA:17905, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC         ChEBI:CHEBI:17180, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.81;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:18657, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC         ChEBI:CHEBI:17180, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.81;
CC   -!- PATHWAY: Carbohydrate acid metabolism; tartrate degradation; 3-
CC       hydroxypyruvate from D-glycerate: step 1/1.
CC   -!- INDUCTION: By tartrate.
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DR   EMBL; U32375; AAB61624.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70788; -.
DR   SMR; P70788; -.
DR   UniPathway; UPA00839; UER00804.
DR   GO; GO:0008465; F:glycerate dehydrogenase activity; IEA:RHEA.
DR   GO; GO:0008887; F:glycerate kinase activity; IEA:InterPro.
DR   GO; GO:0016618; F:hydroxypyruvate reductase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1480.10; -; 1.
DR   Gene3D; 3.40.50.10180; -; 1.
DR   InterPro; IPR037035; GK-like_C_sf.
DR   InterPro; IPR038614; GK_N_sf.
DR   InterPro; IPR007835; MOFRL.
DR   InterPro; IPR025286; MOFRL_assoc_dom.
DR   InterPro; IPR039760; MOFRL_protein.
DR   PANTHER; PTHR12227; PTHR12227; 1.
DR   Pfam; PF13660; DUF4147; 1.
DR   Pfam; PF05161; MOFRL; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase; Plasmid.
FT   CHAIN           1..385
FT                   /note="Putative hydroxypyruvate reductase"
FT                   /id="PRO_0000065681"
SQ   SEQUENCE   385 AA;  38790 MW;  5BD116399C7A9C2C CRC64;
     MGRCVVIGAG KASAAMAAAL DTVWSDVDLS GVVVTRYGHA VPSGRIRIIE ASHPVPDDMS
     VEAAVRIIGA VRDLGPDDLV IALISGGGSS LLVSPAAGMT LADKKAVNKA LLASGATISE
     MNAVRKQLSG IKGGRLAQLA HPARVVTLVI SDVPGDDPSE IASGPTVAND TTIDDAREIV
     SRYRLVLPPA AQDVLANGGA RNCTGKVSSD VRMIASPSMA LDAAAAVAAA NGLTPVILGD
     ALQGEARDVG TVFAGIAMSA STKGLPVRGP AVLLSGGETS VSLPADTKGR GGRNSEFLLS
     LAIGLDGAKG IWALSGDTDG IDGIEDAAGA MIGPDSLARM RGSGIDPRSA LSRHDSYTAF
     KAIDDLVITG PTLTNVNDIR AILIG