ID   TTUD4_AGRVI             Reviewed;         438 AA.
AC   Q44472;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Putative hydroxypyruvate reductase;
DE            EC=1.1.1.81;
GN   Name=ttuD;
OS   Agrobacterium vitis (Rhizobium vitis).
OG   Plasmid pTrAB4.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
OX   NCBI_TaxID=373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AB4;
RX   PubMed=7592429; DOI=10.1128/jb.177.22.6518-6526.1995;
RA   Crouzet P., Otten L.;
RT   "Sequence and mutational analysis of a tartrate utilization operon from
RT   Agrobacterium vitis.";
RL   J. Bacteriol. 177:6518-6526(1995).
CC   -!- FUNCTION: Degrades an unidentified toxic product from the first step of
CC       tartrate degradation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH;
CC         Xref=Rhea:RHEA:17905, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC         ChEBI:CHEBI:17180, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.81;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:18657, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC         ChEBI:CHEBI:17180, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.81;
CC   -!- PATHWAY: Carbohydrate acid metabolism; tartrate degradation; 3-
CC       hydroxypyruvate from D-glycerate: step 1/1.
CC   -!- INDUCTION: By tartrate.
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DR   EMBL; U25634; AAA68699.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q44472; -.
DR   SMR; Q44472; -.
DR   UniPathway; UPA00839; UER00804.
DR   GO; GO:0008465; F:glycerate dehydrogenase activity; IEA:RHEA.
DR   GO; GO:0008887; F:glycerate kinase activity; IEA:InterPro.
DR   GO; GO:0016618; F:hydroxypyruvate reductase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1480.10; -; 1.
DR   Gene3D; 3.40.50.10180; -; 1.
DR   InterPro; IPR037035; GK-like_C_sf.
DR   InterPro; IPR038614; GK_N_sf.
DR   InterPro; IPR007835; MOFRL.
DR   InterPro; IPR025286; MOFRL_assoc_dom.
DR   InterPro; IPR039760; MOFRL_protein.
DR   PANTHER; PTHR12227; PTHR12227; 1.
DR   Pfam; PF13660; DUF4147; 1.
DR   Pfam; PF05161; MOFRL; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase; Plasmid.
FT   CHAIN           1..438
FT                   /note="Putative hydroxypyruvate reductase"
FT                   /id="PRO_0000065682"
SQ   SEQUENCE   438 AA;  44730 MW;  38C75BAFFFB0636B CRC64;
     MQRNRRIEYL EDGRCRMTWN DVSARQVLRR IFDAAVASAD PKIAVVNNLP ERPRGRCVVV
     GAGKASAAMA AAVDAAWPDV DLSGIVVTRY GHAVPAGRIE ILEASHPVPD EMSIKAAEKI
     FAAVQGLGPD DLVVALISGG GSSLLVSPTG KMTLTDKRAV NQALLASGAT ISEMNTVRKH
     LSAIKGGHLA RAALPAKLVT LIISDVPGDD PSEIASGPTV ADPTTLADAA AIIARYGIDL
     PESARAVLVQ GNETPKAGEV AGEIRLVAAP SIALEAAAAA ALDAGLCPLI LGDALEGEAR
     EMGRVMAGIA LSARDKGLPV AAPAVILSGG ESTVSLGAMT EGRGGRNTEF LLSLAVALKG
     ASGIWAIAGD TDGIDGVEDA AGALVAPDSL IRMRDAGIDP RATLSAHDSY TAFKAIGDLV
     VTGPTLTNVN DIRAILIG