ID   TTY1A_XENLA             Reviewed;         449 AA.
AC   Q6AX57;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Protein tweety homolog 1-A;
GN   Name=ttyh1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR   EMBL; BC079745; AAH79745.1; -; mRNA.
DR   RefSeq; NP_001087415.1; NM_001093946.1.
DR   AlphaFoldDB; Q6AX57; -.
DR   SMR; Q6AX57; -.
DR   DNASU; 447239; -.
DR   GeneID; 447239; -.
DR   KEGG; xla:447239; -.
DR   CTD; 447239; -.
DR   Xenbase; XB-GENE-940455; ttyh1.L.
DR   OMA; PREREYQ; -.
DR   OrthoDB; 725378at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 447239; Expressed in brain and 11 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion channel;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..449
FT                   /note="Protein tweety homolog 1-A"
FT                   /id="PRO_0000312243"
FT   TOPO_DOM        1..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..388
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        410..449
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        353
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   449 AA;  50941 MW;  57EF725D9ADBECAD CRC64;
     MSTSHGYRAS WWTNILHQVP HTNFQFEVVD NQFAPQEWPY QQALLFLASI AGLCLAISLI
     LICVYLIRFC CCASQEDDDS KNHRVCCVTW SCVAAVIICC AGIGIGFYGN SETNDGVYQV
     TYSLMNTNHT LTSINLLVSD TVELLSSVVK SDLTQLEEIF SKRTEFLVMI RNTRRQVESV
     AQQLAEISFW KGTELNPNVL AEQVNFIEDY RWLAYILLLL LDLIICLFTL LGLAKRIKWL
     VIVMTVVSFF VLLLSWGSMG LEMATAVGLS DFCSNPDGYV MNQTQMITNI NPDILQYYIS
     CNQDVANPFR QRLTTSQRAL SNIHSQLHGL EREAVPQFPT AEKNLLAVQG MLNTTEGNFH
     HLVALLNCRG LHKDYVDALK GLCYDGMEGI LFLLLFSFLS ALSFTAAVCS LPRAWKRFQN
     RDLDYDDMDE DDPFNPQESK RFVQWQSSI