ID   TTY1B_XENLA             Reviewed;         451 AA.
AC   Q6GM04;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein tweety homolog 1-B;
GN   Name=ttyh1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR   EMBL; BC074289; AAH74289.1; -; mRNA.
DR   RefSeq; NP_001086174.1; NM_001092705.1.
DR   AlphaFoldDB; Q6GM04; -.
DR   SMR; Q6GM04; -.
DR   GeneID; 444603; -.
DR   KEGG; xla:444603; -.
DR   CTD; 444603; -.
DR   Xenbase; XB-GENE-17339952; ttyh1.S.
DR   OrthoDB; 725378at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 444603; Expressed in brain and 18 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion channel;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..451
FT                   /note="Protein tweety homolog 1-B"
FT                   /id="PRO_0000312244"
FT   TOPO_DOM        1..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..214
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        236..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..390
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        412..451
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        355
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   451 AA;  51166 MW;  44F6883A70FE6201 CRC64;
     MSTSHGYRAS WWTYILHQVP HTNFQFEVVD NQFAPQEWSY QQALLFLASI AGLCLAISLV
     LICVYLIKFC CCASQEDDDS KSHRVCCVTW SCVAAVIICC AGIGIGFYGN SETNDGVYQV
     TYSLMNANHT LTSINLLVSD TVELLSSVVK SDLTQLEEIF STRTEFVVMI RNTRRQVESV
     AQQLTEISSF FWKGAELNPS ALAEQVNFIE DYRWLAYILL LLLDLIICLF TLLSLAKQIK
     WLVIVMTVVS FFVLLLSWGS MGLEMATAVG LSDFCSDPDA YVMNQTQMIT NINPDILQYY
     ISCNQDVTNP FRQRLTMSQR ALSNIHSQLH GLEREAVPQF PTAERNVLVV QGMLNTTEGN
     FHHLVALLNC RGLHKDYVDA LKGLCYDGME GILFLLLFSF LSALSFTAAV CSLPRAWKRF
     RNRDLDYDDM DEDDPFNPQE SKRFVQWQSS I