TTY1_DROME
ID TTY1_DROME Reviewed; 970 AA.
AC Q9U6L4; O61343; Q8IQ48; Q9VRG9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein tweety;
DE Short=Dttyh1;
GN Name=tty; ORFNames=CG1693;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Canton-S;
RX PubMed=9520435; DOI=10.1073/pnas.95.7.3731;
RA Maleszka R., de Couet H.G., Miklos G.L.G.;
RT "Data transferability from model organisms to human beings: insights from
RT the functional genomics of the flightless region of Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA Harvey D.A.;
RT "A Drosophila complementary DNA resource.";
RL Science 287:2222-2224(2000).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=8552658; DOI=10.1073/pnas.93.1.447;
RA Maleszka R., Hanes S.D., Hackett R.L., de Couet H.G., Miklos G.L.G.;
RT "The Drosophila melanogaster dodo (dod) gene, conserved in humans, is
RT functionally interchangeable with the ESS1 cell division gene of
RT Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:447-451(1996).
CC -!- FUNCTION: Non-essential protein that probably acts as a chloride
CC channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Flies lacking tty are viable and fertile. Was
CC named 'tweety' after the cartoon character that cannot fly. Indeed, a
CC mutant involving a genomic region that contain tty leads to flies that
CC cannot fly. {ECO:0000269|PubMed:8552658}.
CC -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC28400.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF017777; AAC28400.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE014298; AAF50831.4; -; Genomic_DNA.
DR EMBL; AF184227; AAD55738.1; -; mRNA.
DR PIR; T08424; T08424.
DR RefSeq; NP_542443.4; NM_080712.7.
DR RefSeq; NP_728415.4; NM_167744.4.
DR AlphaFoldDB; Q9U6L4; -.
DR SMR; Q9U6L4; -.
DR STRING; 7227.FBpp0302935; -.
DR TCDB; 1.A.48.1.1; the anion channel tweety (tweety) family.
DR GlyGen; Q9U6L4; 6 sites.
DR PaxDb; Q9U6L4; -.
DR DNASU; 33109; -.
DR EnsemblMetazoa; FBtr0077224; FBpp0076919; FBgn0015558.
DR EnsemblMetazoa; FBtr0329901; FBpp0302935; FBgn0015558.
DR GeneID; 33109; -.
DR KEGG; dme:Dmel_CG1693; -.
DR UCSC; CG1693-RA; d. melanogaster.
DR CTD; 33109; -.
DR FlyBase; FBgn0015558; tty.
DR VEuPathDB; VectorBase:FBgn0015558; -.
DR eggNOG; KOG4433; Eukaryota.
DR GeneTree; ENSGT00950000183060; -.
DR HOGENOM; CLU_012059_0_0_1; -.
DR InParanoid; Q9U6L4; -.
DR OrthoDB; 725378at2759; -.
DR PhylomeDB; Q9U6L4; -.
DR Reactome; R-DME-2672351; Stimuli-sensing channels.
DR BioGRID-ORCS; 33109; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 33109; -.
DR PRO; PR:Q9U6L4; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0015558; Expressed in brain and 10 other tissues.
DR ExpressionAtlas; Q9U6L4; baseline and differential.
DR Genevisible; Q9U6L4; DM.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005254; F:chloride channel activity; ISS:UniProtKB.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR GO; GO:0072320; F:volume-sensitive chloride channel activity; IBA:GO_Central.
DR GO; GO:0006821; P:chloride transport; ISS:FlyBase.
DR CDD; cd07912; Tweety_N; 1.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424; PTHR12424; 1.
DR Pfam; PF04906; Tweety; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion channel;
KW Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..970
FT /note="Protein tweety"
FT /id="PRO_0000312256"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..89
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..219
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..395
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 417..970
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 532..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..870
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 359
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 970 AA; 105828 MW; 625FE41A35647394 CRC64;
MGDYHEFTDQ YKVPVIAKLL HALPHYNITF HKINSTFRPN DEIYLESLGI LGSVPAALLI
VSLLGLLFYL MTRCCDRKPR PAHSITSLKV ALSIVTVMCC AAIGLGLYGN DDLHNGLLEV
LTAGRKVDNL VTTIRNQTHI LENTLTNRIR PQLVELADIF DQPVSNQTAL SKLFVSLNIV
QGNVTLATNA ASDIRRPLMG ISMTHFLTRG DQWELIRWPG TVATLALLLV LCAVLLVGVA
RHSRCALILF SVCGLLAVTG SWLMSGLYLS SSVAVGDLCI SPADFLVSTA PRDLPTNVLL
HYTQCEPGHT NPFTQRLRES QNSLNNARSA MATVMKISLV LFKSSGLQPK LGAVNADLNS
SERLLTQLTA LVDCKAVHHN FLAAARGLCE GGLLGLVLML IASFIAAILL TIMVWVDSHT
WIYIRKRNDY AQVDEPSYIS HPAPQNHQQM MNAARTLPRN HNGHFSPPVI SGSHTLQHPS
KRQQHEMMAH AHIQQNMRAM GTHTLGRLPS HNHSPTHMTG PNNAAAVAAA ANAAANMPPT
TQAAQQQQQQ QAQQQQQQAQ QQLGGPQPIY CHHPHQHPHP HPHQHPHSHS AAAVAAAVQH
QHAIYHQQQA QQYGTYTTAA HHAPHHLGPG QSQIYQQIPA HLAPQLAANG NPHSIYQPLV
AVSQGSIYVS NMATMRRQNS QGGPQIPAHQ HPPSLHQQQQ QPPPPSQQQQ QLHQLKSPQQ
HQQQLQQHQQ QQQQQHHQQQ HHQQQHQQQQ QQHHQQQQPN ESDVVPISTA MDTAIYDRDK
QIYKCSTLRQ GGKFDPKYKP SILNCPLPEI PKDAEQPKVE SIYEQRQQAH HQNYSKTLQR
PPMMLPPQMK AIPPPRIGTP TSPPPPVAQP LNESNGGVPS GLQNGGAVVG GGGANANEDT
SLPPPPLEAQ TEATKARMGA GPAANGKVLH NGGGGGSVGG GGGGAVDDDD DLPPPPPAIT
DESNYAVTEL
