ID   TTY2L_DANRE             Reviewed;         531 AA.
AC   Q6NUZ2;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Protein tweety homolog 2-like;
GN   Name=ttyh2l; ORFNames=zgc:85736;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable large-conductance Ca(2+)-activated chloride channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR   EMBL; BC068374; AAH68374.1; -; mRNA.
DR   RefSeq; NP_998421.1; NM_213256.1.
DR   AlphaFoldDB; Q6NUZ2; -.
DR   SMR; Q6NUZ2; -.
DR   STRING; 7955.ENSDARP00000018866; -.
DR   PaxDb; Q6NUZ2; -.
DR   GeneID; 406540; -.
DR   KEGG; dre:406540; -.
DR   CTD; 406540; -.
DR   ZFIN; ZDB-GENE-040426-2394; ttyh2l.
DR   eggNOG; KOG4433; Eukaryota.
DR   InParanoid; Q6NUZ2; -.
DR   OrthoDB; 725378at2759; -.
DR   PhylomeDB; Q6NUZ2; -.
DR   PRO; PR:Q6NUZ2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR   GO; GO:0072320; F:volume-sensitive chloride channel activity; IBA:GO_Central.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cell membrane; Chloride; Chloride channel; Glycoprotein;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..531
FT                   /note="Protein tweety homolog 2-like"
FT                   /id="PRO_0000312248"
FT   TOPO_DOM        1..44
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..389
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        411..531
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        283
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        352
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   531 AA;  59535 MW;  3C663279113C9305 CRC64;
     MASSRQDYIA PWWTYWLHNF PHLNFNFQTV DNTFKPEDAS YQQSLVFLAC VSAVALGLCL
     LLLSVYLTCL CCCRREEDEE VKRPDTCCVT WAAVITGLVI CSAVGVGFYG NSETNDGVYQ
     LTYSIYNANH TLGGIGSMVG NSLGSMQVGL KEHLERLDEI FSPRGDYTQT LRFMQQMADN
     IIQQLTAMPE TRKVQVDLAA IADRTAFIEY YRWLTYLLLL ILDLVICLLA CLALAKQSRW
     LLTVIMVCGM LTLIMSWASL GAGTATAVGT SDFCVSPDKY IVNQTKGTLS SDIVHYYLYC
     SQSLPNPFQQ SLTIFQRSLT TMQIQVQGLL QFAVVVFPTA EKDLLGIQRL LNSSEFNLHQ
     LTALLDCRSL HKDYLEALLG VCYDGVEGLL YLCLFSLLAA CAFCALLCAV PRAWMLIAIR
     DRDYDDIDEE DPFNPTRRFN AYNPSRAQVH SFCSYSSSMG SQTSLQPPLQ ATSSTPEYMN
     QSMLFERNPR YENVPLIGSG SPPPSYSPSM RTTYLSMTDA QIRHFGTDFQ V