ID   TTYH1_BOVIN             Reviewed;         450 AA.
AC   Q2KJ98;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein tweety homolog 1;
GN   Name=TTYH1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable chloride channel. May be involved in cell adhesion
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR   EMBL; BC105448; AAI05449.1; -; mRNA.
DR   RefSeq; NP_001070483.1; NM_001077015.1.
DR   AlphaFoldDB; Q2KJ98; -.
DR   SMR; Q2KJ98; -.
DR   STRING; 9913.ENSBTAP00000004515; -.
DR   PaxDb; Q2KJ98; -.
DR   GeneID; 767943; -.
DR   KEGG; bta:767943; -.
DR   CTD; 57348; -.
DR   eggNOG; KOG4433; Eukaryota.
DR   InParanoid; Q2KJ98; -.
DR   OrthoDB; 725378at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030868; C:smooth endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR   GO; GO:0072320; F:volume-sensitive chloride channel activity; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell membrane; Chloride; Chloride channel; Glycoprotein;
KW   Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..450
FT                   /note="Protein tweety homolog 1"
FT                   /id="PRO_0000312238"
FT   TOPO_DOM        1..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..88
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..214
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        236..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..390
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        412..450
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          427..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         440
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D3A9"
FT   CARBOHYD        130
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        355
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   450 AA;  49230 MW;  6841F75BC2D06407 CRC64;
     MGAPPGYRPS AWVHLLHQLP RADFQLRPVP SAFAPQEREY QQALLLVAAL AGLGLGLSLI
     FIAVYLIRFC CCRPPEPPGA KSPPPGGGCV TWNCIAALLV GCAGIGVGFY GNSETSDGVS
     QLSSALLHAN HTLTAIDHLV LEMVERLNEA VRTELTTLEE VLTQRTELVA AARGARRQAE
     TVAQQLQGLA FWRGVPLSPL QVAEDVSFVE EYRWLAYVLL LLLELLVCLF TLLGLARQSK
     WLVIVMTVMS LLVLVLSWGS MGLEAATAVG LSDFCSSPDS YILNLTQEET GLGSDILNYY
     FLCNQAVSNP FQQRLTLSQR ALANIHSQLQ GLEREAVPQF PSAQKPVLSL EETLNVTEGN
     FHQLVALLHC RGLHKDYGSA LRGLCEDTLE GLLFLLLFSL LSAGALATVL CSLPRAWALF
     PPSDDYEDTD DDDPFNPQES KRFVQWQSSI