TTYH1_CAEEL
ID TTYH1_CAEEL Reviewed; 519 AA.
AC Q20332; Q7JM69; Q8MQ53; Q9U3F6;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein tweety homolog 1;
GN Name=ttyh-1; ORFNames=F42E11.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=15888633; DOI=10.1093/glycob/cwi075;
RA Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H., Mahuran D.J.;
RT "Identification of the hydrophobic glycoproteins of Caenorhabditis
RT elegans.";
RL Glycobiology 15:952-964(2005).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-163 AND ASN-176, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- FUNCTION: Probable chloride channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q20332-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q20332-2; Sequence=VSP_029773, VSP_029774;
CC Name=c;
CC IsoId=Q20332-3; Sequence=VSP_029775;
CC -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR EMBL; Z66562; CAB60289.1; -; Genomic_DNA.
DR EMBL; Z66562; CAA91464.1; -; Genomic_DNA.
DR EMBL; Z66562; CAD44123.1; -; Genomic_DNA.
DR PIR; T22091; T22091.
DR RefSeq; NP_509903.1; NM_077502.4. [Q20332-1]
DR RefSeq; NP_509904.1; NM_077503.4.
DR RefSeq; NP_741904.1; NM_171973.5. [Q20332-3]
DR AlphaFoldDB; Q20332; -.
DR SMR; Q20332; -.
DR BioGRID; 46237; 1.
DR DIP; DIP-27409N; -.
DR STRING; 6239.F42E11.2a; -.
DR iPTMnet; Q20332; -.
DR EPD; Q20332; -.
DR PaxDb; Q20332; -.
DR PeptideAtlas; Q20332; -.
DR EnsemblMetazoa; F42E11.2a.1; F42E11.2a.1; WBGene00009632. [Q20332-1]
DR EnsemblMetazoa; F42E11.2b.1; F42E11.2b.1; WBGene00009632. [Q20332-2]
DR EnsemblMetazoa; F42E11.2c.1; F42E11.2c.1; WBGene00009632. [Q20332-3]
DR GeneID; 181328; -.
DR KEGG; cel:CELE_F42E11.2; -.
DR UCSC; F42E11.2c; c. elegans. [Q20332-1]
DR CTD; 181328; -.
DR WormBase; F42E11.2a; CE03309; WBGene00009632; ttyh-1. [Q20332-1]
DR WormBase; F42E11.2b; CE23715; WBGene00009632; ttyh-1. [Q20332-2]
DR WormBase; F42E11.2c; CE31512; WBGene00009632; ttyh-1. [Q20332-3]
DR eggNOG; KOG4433; Eukaryota.
DR GeneTree; ENSGT00950000183060; -.
DR InParanoid; Q20332; -.
DR OMA; GSHVLNP; -.
DR OrthoDB; 725378at2759; -.
DR PhylomeDB; Q20332; -.
DR Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR PRO; PR:Q20332; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00009632; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR GO; GO:0072320; F:volume-sensitive chloride channel activity; IBA:GO_Central.
DR CDD; cd07912; Tweety_N; 1.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424; PTHR12424; 1.
DR Pfam; PF04906; Tweety; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Chloride; Chloride channel;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..519
FT /note="Protein tweety homolog 1"
FT /id="PRO_0000312255"
FT TOPO_DOM 1..42
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..395
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 417..519
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 459..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15888633"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 341
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 348
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 96..110
FT /note="FMLGVCLFANEHVNR -> DKLFAFVIIMPIARV (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_029773"
FT VAR_SEQ 111..519
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_029774"
FT VAR_SEQ 464..497
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_029775"
SQ SEQUENCE 519 AA; 58259 MW; 48BC0372A73F81EA CRC64;
MTFASFLINF YSVIPRLNFK FHWTNDVFNL EWSSEYFQAL ALVACLGAAV SLLLLVTIII
VWICQACHKN ETTGKTRRRV RRLSTVLFII SVLCFFMLGV CLFANEHVNR GMSISINSII
NTKKSYQIST AQISQFQEAA LNTTVHLKNL EDTVHVESKK TKNATIVQQI DQILTNITDE
IDIIAKNGKL FQAKHGDDIG KLEKIRKVLS LYESERWAFL VILLSITMVV LFTGVVAFCK
QSKKGAVVFS AIGFFIFVVV WLLISISLPL TIALADFCRD GDQVTRKNLG NLYETVQFYN
TCVPVTTHDN LPLPVARHVA LLNNIPANKS QLDRLMEVAF NSSAAIVNSS SAVGDDITKM
LKLAGAVSSS SSCYVFHDDV VNFYYGTCNQ SVAGMSIYML SILLLGVFLF ILLIVVSKTW
NLFSRLPNEY TEVDEDDPFF PRGVNDSTIP VDIYGTHVYN PRTRDRTEPS TNTTSGTADE
PNAPLWSQNV TVPLVSNSMS RQPFMSDHPY NNYEDRYNM
