TTYH1_RAT
ID TTYH1_RAT Reviewed; 450 AA.
AC P0C5X8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Protein tweety homolog 1;
GN Name=Ttyh1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=17116230; DOI=10.1111/j.1471-4159.2006.04237.x;
RA Matthews C.A., Shaw J.E., Hooper J.A., Young I.G., Crouch M.F.,
RA Campbell H.D.;
RT "Expression and evolution of the mammalian brain gene Ttyh1.";
RL J. Neurochem. 100:693-707(2007).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Probable chloride channel. May be involved in cell adhesion.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17116230};
CC Multi-pass membrane protein {ECO:0000269|PubMed:17116230}.
CC -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR EMBL; AABR03001833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001099695.1; NM_001106225.1.
DR RefSeq; XP_006228278.1; XM_006228216.3.
DR AlphaFoldDB; P0C5X8; -.
DR SMR; P0C5X8; -.
DR STRING; 10116.ENSRNOP00000062088; -.
DR GlyGen; P0C5X8; 3 sites.
DR iPTMnet; P0C5X8; -.
DR PhosphoSitePlus; P0C5X8; -.
DR SwissPalm; P0C5X8; -.
DR PaxDb; P0C5X8; -.
DR PRIDE; P0C5X8; -.
DR Ensembl; ENSRNOT00000068459; ENSRNOP00000062088; ENSRNOG00000032699.
DR GeneID; 292597; -.
DR KEGG; rno:292597; -.
DR UCSC; RGD:1310103; rat.
DR CTD; 57348; -.
DR RGD; 1310103; Ttyh1.
DR eggNOG; KOG4433; Eukaryota.
DR GeneTree; ENSGT00950000183060; -.
DR HOGENOM; CLU_023758_1_0_1; -.
DR InParanoid; P0C5X8; -.
DR OMA; SYSPSIW; -.
DR OrthoDB; 725378at2759; -.
DR PhylomeDB; P0C5X8; -.
DR Reactome; R-RNO-2672351; Stimuli-sensing channels.
DR PRO; PR:P0C5X8; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000032699; Expressed in Ammon's horn and 20 other tissues.
DR ExpressionAtlas; P0C5X8; baseline and differential.
DR Genevisible; P0C5X8; RN.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0031527; C:filopodium membrane; ISO:RGD.
DR GO; GO:0032433; C:filopodium tip; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030868; C:smooth endoplasmic reticulum membrane; ISO:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0005509; F:calcium ion binding; ISO:RGD.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR GO; GO:0072320; F:volume-sensitive chloride channel activity; ISO:RGD.
DR GO; GO:0098609; P:cell-cell adhesion; ISO:RGD.
DR GO; GO:0031589; P:cell-substrate adhesion; ISO:RGD.
DR GO; GO:0006821; P:chloride transport; ISO:RGD.
DR GO; GO:0046847; P:filopodium assembly; ISO:RGD.
DR GO; GO:0000278; P:mitotic cell cycle; ISO:RGD.
DR CDD; cd07912; Tweety_N; 1.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424; PTHR12424; 1.
DR Pfam; PF04906; Tweety; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Cell membrane; Chloride; Chloride channel; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..450
FT /note="Protein tweety homolog 1"
FT /id="PRO_0000312242"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..390
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 412..450
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 428..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 440
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D3A9"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 284
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 49032 MW; 25BC429B4D7BFCF3 CRC64;
MGAPPGYRPS AWVHLLHQLP RADFQLRPVP SGFAPRDQEY QQALLLVAAL AGLGLGLSLI
FIAVYLIRFC CCRPPEPPGA KSPPPGGGCV TWSCIAALLV GCAGIGIGFY GNSETSDGVS
QLSSALQHAN HTLSTIDDLV LETVERLGEA VRTELTTLEE VLSERVELVA ATRGARRQAE
AAAQHLQGLA FWQGVSLSPV QVAEDVTFVE EYRWLAYVLL LLLVLLVCLF TLLGLAKQSK
WLVVVMTAMS LLVLVLSWGS MGLEAATAVG LSDFCSNPDT YVLNLTQEET GISSDILNYY
FLCNQAVSNP FQQRLTLSQR ALASIHSQLQ GLEREASPQF PAAQKPLLSL EETLNVTERS
FHQLVALLHC RSLHKDYGSA LRGLCEDALE GLLFLMLFSL LSAGALATTL CSLPRAWALF
PPSDDYDDTD DDDPFNPQES KRFVQWQSSI
