ID   TTYH1_XENTR             Reviewed;         449 AA.
AC   Q0V9V9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Protein tweety homolog 1;
GN   Name=ttyh1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q0V9V9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q0V9V9-2; Sequence=VSP_029767;
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR   EMBL; BC121375; AAI21376.1; -; mRNA.
DR   RefSeq; NP_001072899.1; NM_001079431.1. [Q0V9V9-2]
DR   RefSeq; XP_012822220.1; XM_012966766.2. [Q0V9V9-1]
DR   AlphaFoldDB; Q0V9V9; -.
DR   SMR; Q0V9V9; -.
DR   DNASU; 780361; -.
DR   GeneID; 780361; -.
DR   KEGG; xtr:780361; -.
DR   CTD; 57348; -.
DR   Xenbase; XB-GENE-940450; ttyh1.
DR   eggNOG; KOG4433; Eukaryota.
DR   InParanoid; Q0V9V9; -.
DR   OrthoDB; 725378at2759; -.
DR   Reactome; R-XTR-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003389; Expressed in brain and 9 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030868; C:smooth endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR   GO; GO:0072320; F:volume-sensitive chloride channel activity; IBA:GO_Central.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Chloride; Chloride channel;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..449
FT                   /note="Protein tweety homolog 1"
FT                   /id="PRO_0000312245"
FT   TOPO_DOM        1..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..388
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        410..449
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        353
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         438..449
FT                   /note="ESKRFVQWQSSI -> ARREMLHVTGRPHLPSFYSYSSSCDSHSSLRVSAPP
FT                   ISNAPVSQYMNQSALSSGNPRFENIPLIDRQSPPPSYSPSMRTSFISATQEETDTPCRT
FT                   DVAF (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_029767"
SQ   SEQUENCE   449 AA;  50958 MW;  BCC923C1F3B739B0 CRC64;
     MSSSHGYRAS WWTYILHQVP HTNFQFEVVD NQFAPQEWPY QQALLFLASI AGLCLAISLI
     LICVYLIRFC CCSSQEDDDS KSHRVCCVTW SCVAAVIICC AGIGIGFYGN SETNDGVYQV
     TYSLMNANHT LTSINLLISD TVELLSSVVR SDLTQLEEIF SKRTEFLVMI RNTRRQVESV
     AQQLAEISFW KGPEPNPNAL AEQVNFIEDY RWLAYILLLL LDLIICLFTL LGLAKQIKWL
     VIVMTVVSFF VLLLSWGSMG LEMATAVGLS DFCSDPDAYV MNQTQAITNI NPDILQYYIS
     CNQDVTNPFR QRLTMSQRAL SNIHSQLHGL EREAVPQFPT AEKNLLVVQG MLNTTEGNFH
     HLVALLNCRG LHKDYVDALK GLCYDGMEGI LFLLLFSFLS ALSFTAAICS LPRAWKRFQN
     RDLDYDDMDE DDPFNPQESK RFVQWQSSI