ID   TTYH2_XENLA             Reviewed;         534 AA.
AC   Q7ZWN9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein tweety homolog 2;
GN   Name=ttyh2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable large-conductance Ca(2+)-activated chloride channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR   EMBL; BC046859; AAH46859.1; -; mRNA.
DR   RefSeq; NP_001080592.1; NM_001087123.1.
DR   AlphaFoldDB; Q7ZWN9; -.
DR   SMR; Q7ZWN9; -.
DR   DNASU; 380284; -.
DR   GeneID; 380284; -.
DR   KEGG; xla:380284; -.
DR   CTD; 380284; -.
DR   Xenbase; XB-GENE-866564; ttyh2.S.
DR   OMA; HYSGEFP; -.
DR   OrthoDB; 725378at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 380284; Expressed in neurula embryo and 14 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cell membrane; Chloride; Chloride channel; Glycoprotein;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..534
FT                   /note="Protein tweety homolog 2"
FT                   /id="PRO_0000312249"
FT   TOPO_DOM        1..44
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..388
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        410..534
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        197
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        352
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   534 AA;  59299 MW;  2757C0EA358BF0F4 CRC64;
     MATARVEYIA PWWVYWLHNL PHVDFSLQRE SGDFNPKDPG YQQTLLFVAL FIALCAAVNL
     LFVSGYLICL CCCKKEDETE TKMTSSCCVT WTAAVSGLLC CAAVGIGFYG NSETNDGVYQ
     LTYSLDNANH TLAGIDSLVS NTNAKMKEDL DQHLFRLNEI FAARGDYIQS LRFMQQMAGN
     IIQQLTSLPN WQGTSVNFSE IARNASIIEY YRWLSYLILF ITDVVICLVT CLGLAKKSKC
     LLLTMLCCGL IALMLSWASL ALETSSAVGT SDFCVAPDKF ILNMTPDQIT ADVVHYYLYC
     SQSQRNPFQQ ALTVFQRSLT TMQIQIQGLL QFAVPLFPTA QKDLLGIQLL LNTSESNLHQ
     ITALLDCRGL HKDYLEALIG ICYDGVEGLL YLSLFSLLAA VAFTAMVCAM PRAWKHLAAR
     DRDYNDVDDE DPFNPQARRI AVHNPNRGQL RSFCSYSSSL GSQASLQPPA QTVSNAQAAE
     YMNQAALFGG NPRYENVPLI GRGSPPPTYS PTMRATYLSM NEESPNIYSN VFPA