ID   TTYH3_DANRE             Reviewed;         560 AA.
AC   Q32LT7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein tweety homolog 3;
GN   Name=ttyh3; ORFNames=zgc:123242;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable large-conductance Ca(2+)-activated chloride channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR   EMBL; BC109434; AAI09435.1; -; mRNA.
DR   RefSeq; NP_001032464.1; NM_001037387.2.
DR   AlphaFoldDB; Q32LT7; -.
DR   SMR; Q32LT7; -.
DR   STRING; 7955.ENSDARP00000108518; -.
DR   PaxDb; Q32LT7; -.
DR   PRIDE; Q32LT7; -.
DR   GeneID; 798421; -.
DR   KEGG; dre:798421; -.
DR   CTD; 798421; -.
DR   ZFIN; ZDB-GENE-051120-105; ttyh3b.
DR   eggNOG; KOG4433; Eukaryota.
DR   InParanoid; Q32LT7; -.
DR   OrthoDB; 725378at2759; -.
DR   PhylomeDB; Q32LT7; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q32LT7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR   GO; GO:0072320; F:volume-sensitive chloride channel activity; IBA:GO_Central.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cell membrane; Chloride; Chloride channel; Glycoprotein;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..560
FT                   /note="Protein tweety homolog 3"
FT                   /id="PRO_0000312253"
FT   TOPO_DOM        1..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..387
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        409..560
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          415..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..552
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        352
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   560 AA;  62192 MW;  288ABB92E40D04F6 CRC64;
     MAAVVNYSPP WWVNLFHRLP HFNLQFQQTS SDFRPDDSDY QKAVLLLGAA ALVCLALDLL
     FLLFYSFWLC CCRRKNHDSP NADCCCTAWC VIIATLVCSA GIAVGFYGNG ETCDGVTRLT
     YSLRHANQTV AGIDKLVSES TSSLNETLME GLVQLETVYS KQTDYLSIVQ KLQGQLDELI
     NLMLGVPFWS SNDLSLDHLA SITEQYDWYR WLGYLGLLLF DVIICLLVLV GLIRNSRSIL
     IGVCFLGVLT LVISWASLGL EFSFAVGASD FCVSPDSYIT KVTRENAVIN QDILQYYLKC
     SMGQTNPFQQ KLSGSHKALV EMQDDVSELL RSAIRDFPKT KSNLEEMQGV LNSTEVSLHH
     LTALVDCRSL HMDYVQALTG LCYDGVEGLI YLVLFSFVTA LMFSSIVCSV PHTWQSKRSE
     EEDGDETSAT LGSRAPHDNL YRVHMPSLYS CGSSTYGNEA SLPAAAHTVS NAPVTEYMSQ
     NANFQTPRCE NTPLIGRESP PPSYTSSMRA KYLATSRPDQ PRPTESQNGL EPNMRPDLTS
     RSAPNSRPNS AIHRPHSAIH