ID   TTYH3_XENLA             Reviewed;         522 AA.
AC   Q6GPA5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein tweety homolog 3;
GN   Name=ttyh3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable large-conductance Ca(2+)-activated chloride channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tweety family. {ECO:0000305}.
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DR   EMBL; BC073236; AAH73236.1; -; mRNA.
DR   RefSeq; NP_001085713.1; NM_001092244.1.
DR   AlphaFoldDB; Q6GPA5; -.
DR   SMR; Q6GPA5; -.
DR   GeneID; 444139; -.
DR   KEGG; xla:444139; -.
DR   CTD; 444139; -.
DR   Xenbase; XB-GENE-941475; ttyh3.S.
DR   OMA; RIDLYDW; -.
DR   OrthoDB; 725378at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 444139; Expressed in spleen and 19 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cell membrane; Chloride; Chloride channel; Glycoprotein;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..522
FT                   /note="Protein tweety homolog 3"
FT                   /id="PRO_0000312254"
FT   TOPO_DOM        1..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..386
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        408..522
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          483..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..511
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        351
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   522 AA;  58981 MW;  F53029D8859159F1 CRC64;
     MAAAISYTPP WWVNLLHRLP HLNLQWESLN GDFRPEDPDY QQSLMLLACV ALSCLALDLL
     FLLFYSFWFC CRHRKTEENT NADCCCTVWC VIVATLVCSA GIAVGFYGNG ETSDGIHRVT
     YSIRHVNRTM AGIHDRVSDT TTSLNQTVEP CLQNLEVMFT KQTDYLRIVQ RLQSLLYTLV
     QQTSEIPFWK NHYLLDEFAA QVDLFDWYRW LGYLGLLLFH VFICLLVLFG LIRNSKGTLI
     CVCFLGMMAL IISWASMGLE LAVAVGSSDF CVNPDTFVSK MVEEKSVLRA DILNYYLVCN
     TGSPNPFQQM LSSGHKALVE MQDDVRDLLR SAVKEYPNSK DYLVCIQGVL NSTEINLQHL
     TALVDCRGLH LDYVQSLTGF CYDGVEGLIY LVLFSFVTAL MFSSIVCSVP HTWQQRRANY
     EEGDEETTTP GTRQTHDNLY RVHMPSLYSC GSSYGSETSI PAAAHTVSNA PVTEYMSQNA
     NFQNPRCENT PLIGRESPPP SYTSSMRAKY LATNRPETDP VH