ID   TU142_LOPOL             Reviewed;          88 AA.
AC   P0CI13;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Turripeptide Lol142;
DE   AltName: Full=OL142;
DE   Flags: Precursor;
OS   Lophiotoma olangoensis (Sea snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Turridae; Iotyrris.
OX   NCBI_TaxID=2420066;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17886885; DOI=10.1002/jez.b.21195;
RA   Imperial J.S., Kantor Y., Watkins M., Heralde F.M. III, Stevenson B.,
RA   Chen P., Hansson K., Stenflo J., Ownby J.P., Bouchet P., Olivera B.M.;
RT   "Venomous auger snail Hastula (Impages) hectica (Linnaeus, 1758): molecular
RT   phylogeny, foregut anatomy and comparative toxinology.";
RL   J. Exp. Zool. B Mol. Dev. Evol. 308:744-756(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-25 AND 53-88.
RC   TISSUE=Venom duct;
RX   PubMed=16477526; DOI=10.1007/s00239-005-0010-x;
RA   Watkins M., Hillyard D.R., Olivera B.M.;
RT   "Genes expressed in a turrid venom duct: divergence and similarity to
RT   conotoxins.";
RL   J. Mol. Evol. 62:247-256(2006).
CC   -!- FUNCTION: Acts as a neurotoxin by inhibiting an ion channel.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IX (C-C-C-C-C-C).
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the conopeptide P-like superfamily.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0CI13; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..50
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000402144"
FT   CHAIN           53..88
FT                   /note="Turripeptide Lol142"
FT                   /id="PRO_0000402145"
FT   DISULFID        55..70
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..85
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   88 AA;  9824 MW;  D1C787A7739C5C52 CRC64;
     MATTMTVVLI TSVLLVLAEI FPRDTDGQAA HKSTDQLSQL VDHLKLRKLS RRQYCPSNTC
     NERDECPGNC NDCEYVPGTG PNKRCVKK