ID   TU91_IOTCI              Reviewed;          47 AA.
AC   P0DKM8;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Turripeptide Ici9.1;
DE   AltName: Full=Turripeptide OL11-like;
DE   Flags: Fragment;
OS   Iotyrris cingulifera (Sea snail) (Pleurotoma cingulifera).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Turridae; Iotyrris.
OX   NCBI_TaxID=553733;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16477526; DOI=10.1007/s00239-005-0010-x;
RA   Watkins M., Hillyard D.R., Olivera B.M.;
RT   "Genes expressed in a turrid venom duct: divergence and similarity to
RT   conotoxins.";
RL   J. Mol. Evol. 62:247-256(2006).
CC   -!- FUNCTION: Acts as a neurotoxin by inhibiting an ion channel (By
CC       similarity). May also act as a serine protease inhibitor, since it
CC       possess the kazal serine protease inhibitor signature. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IX (C-C-C-C-C-C).
CC   -!- SIMILARITY: Belongs to the conopeptide P-like superfamily.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0DKM8; -.
DR   SMR; P0DKM8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Protease inhibitor; Secreted; Serine protease inhibitor; Toxin.
FT   CHAIN           <1..47
FT                   /note="Turripeptide Ici9.1"
FT                   /id="PRO_0000419842"
FT   DOMAIN          <1..47
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            7..8
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        1..31
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        5..24
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        13..45
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   NON_TER         1
SQ   SEQUENCE   47 AA;  5115 MW;  AD61E8AF4983C1CE CRC64;
     CLSVCSMEYW PVCGSDGKTY PNECHLTSEA CMSNTDITVA HVGKCDQ