ID   TUB1_CAEBR              Reviewed;         424 AA.
AC   A8WN62;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Tubby protein homolog 1 {ECO:0000250|UniProtKB:Q09306};
GN   Name=tub-1 {ECO:0000312|WormBase:CBG00741};
GN   ORFNames=CBG00741 {ECO:0000312|WormBase:CBG00741};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP21917.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Has a role in fat regulation independent of daf-16.
CC       Implicated in ciliar sensory function which is required for normal
CC       sensory behavior such as chemotaxis. Functions in life span control via
CC       the insulin/IGF-1 pathway. Thought to be involved in neuronal
CC       trafficking (By similarity). {ECO:0000250|UniProtKB:Q09306}.
CC   -!- SUBUNIT: Interacts with rgb-3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q09306}. Cell
CC       projection {ECO:0000250|UniProtKB:Q09306}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:Q09306}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q09306}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q09306}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; HE600999; CAP21917.1; -; Genomic_DNA.
DR   RefSeq; XP_002630305.1; XM_002630259.1.
DR   AlphaFoldDB; A8WN62; -.
DR   SMR; A8WN62; -.
DR   STRING; 6238.CBG00741; -.
DR   EnsemblMetazoa; CBG00741.1; CBG00741.1; WBGene00024084.
DR   GeneID; 8571820; -.
DR   KEGG; cbr:CBG_00741; -.
DR   CTD; 8571820; -.
DR   WormBase; CBG00741; CBP00205; WBGene00024084; Cbr-tub-1.
DR   eggNOG; KOG2502; Eukaryota.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   InParanoid; A8WN62; -.
DR   OMA; KSPQWND; -.
DR   OrthoDB; 1445357at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR   GO; GO:0097500; P:receptor localization to non-motile cilium; IEA:EnsemblMetazoa.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cell projection; Chemotaxis; Cytoplasm; Lipid metabolism;
KW   Reference proteome; Sensory transduction.
FT   CHAIN           1..424
FT                   /note="Tubby protein homolog 1"
FT                   /id="PRO_0000397234"
FT   REGION          19..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  48362 MW;  8B8339C7D1D601FC CRC64;
     MSDTNSAWIE QNLQRQRKML EDKQKQKRHQ SAGSVRTTTT TSSMSMNNMK DYPAFETSLP
     FSMSDHTSNM NTPLIPTPQA PPRNHTLTTR QSSMPATDTL IQINDYPEND ISAKLSKVNL
     TPCVVSDDED SDRRSYRESP WHNDIVADKI KTDILPDYNY IKNNLQKFVD EPAQEHCLYR
     CSITRHKSGV DKTMYPTYYL HLEEMDTDKK AKIFLLAARK RKKSTTANYL LSTDPTNLSR
     EGDGYCAKVR SNALGTHFTI YDNGHNPKKT DNQFSIRQEL AAVIYETNVL GFKGPRKMTV
     IMPGIEPGND SKPAVRCIHR PVLEKHTLLE KNRSGDTNSL KVLTNKSPQW NDETQSYVLN
     FHGRVTQASV KNFQIIHPNS PEYIVMQFGR VSEDEFTMDF RYPLSAVQAF GIAMTSFHGK
     LACE