TUBE2_BPT7
ID TUBE2_BPT7 Reviewed; 794 AA.
AC P03747;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Tail tubular protein gp12;
DE AltName: Full=Gene product 12;
DE Short=Gp12;
GN OrderedLocusNames=12;
OS Escherichia phage T7 (Bacteriophage T7).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus.
OX NCBI_TaxID=10760;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=6864790; DOI=10.1016/s0022-2836(83)80282-4;
RA Dunn J.J., Studier F.W.;
RT "Complete nucleotide sequence of bacteriophage T7 DNA and the locations of
RT T7 genetic elements.";
RL J. Mol. Biol. 166:477-535(1983).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH GP8; GP11 AND GP17.
RX PubMed=23884409; DOI=10.1074/jbc.m113.491209;
RA Cuervo A., Pulido-Cid M., Chagoyen M., Arranz R., Gonzalez-Garcia V.A.,
RA Garcia-Doval C., Caston J.R., Valpuesta J.M., van Raaij M.J.,
RA Martin-Benito J., Carrascosa J.L.;
RT "Structural characterization of the bacteriophage T7 tail machinery.";
RL J. Biol. Chem. 288:26290-26299(2013).
CC -!- FUNCTION: Structural component of the short non-contractile tail. The
CC tail complex is involved in viral genome delivery. Forms the end of the
CC tail, including the canonical tube, the nozzle, and the small
CC extensions below the fibers. Once the tail tubular structure is formed,
CC the interface between gp11 and gp12 generates the proper environment to
CC interact with the six gp17 trimers. {ECO:0000269|PubMed:23884409}.
CC -!- SUBUNIT: Interacts with head-to-tail connector protein gp8, the tail
CC component gp11, and the fiber protein gp17.
CC {ECO:0000269|PubMed:23884409}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:23884409}.
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DR EMBL; V01146; CAA24430.1; -; Genomic_DNA.
DR PIR; A04372; TLBPB7.
DR RefSeq; NP_042000.1; NC_001604.1.
DR PDB; 6R21; EM; 3.33 A; a/b/c/d/e/f=1-794.
DR PDB; 7BOY; EM; 3.80 A; s/t/u/v/w/x=1-794.
DR PDB; 7EY7; EM; 4.30 A; s/t/u/v/w/x=1-794.
DR PDB; 7EY9; EM; 3.40 A; s/t/u/v/w/x=1-794.
DR PDBsum; 6R21; -.
DR PDBsum; 7BOY; -.
DR PDBsum; 7EY7; -.
DR PDBsum; 7EY9; -.
DR SMR; P03747; -.
DR MINT; P03747; -.
DR GeneID; 1261024; -.
DR KEGG; vg:1261024; -.
DR Proteomes; UP000000840; Genome.
DR GO; GO:0098026; C:virus tail, tube; IEA:UniProtKB-KW.
DR GO; GO:0099002; P:viral genome ejection through host cell envelope, short tail mechanism; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome;
KW Viral genome ejection through host cell envelope;
KW Viral penetration into host cytoplasm; Viral short tail ejection system;
KW Viral tail protein; Viral tail tube protein; Virion;
KW Virus entry into host cell.
FT CHAIN 1..794
FT /note="Tail tubular protein gp12"
FT /id="PRO_0000106526"
FT STRAND 4..8
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 20..22
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 31..35
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 38..44
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 48..56
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 57..59
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 65..70
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 76..81
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 86..90
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 105..107
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 112..114
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 117..120
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 125..128
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 130..132
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 141..145
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 148..156
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 164..169
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 172..178
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 184..190
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 193..207
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 209..215
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 217..223
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 238..240
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 243..247
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 249..252
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 254..257
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 266..269
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 273..275
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 280..283
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 286..289
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 305..307
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 310..313
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 316..318
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 321..324
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 335..337
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 342..345
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 350..354
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 357..362
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 365..368
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 382..384
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 387..389
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 405..409
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 412..416
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 421..424
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 426..429
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 432..434
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 438..441
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 447..449
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 454..456
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 458..463
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 465..475
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 477..481
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 483..487
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 488..491
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 496..498
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 502..506
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 507..510
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 511..515
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 517..519
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 522..531
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 534..544
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 551..565
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 568..577
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 594..601
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 604..606
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 609..612
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 613..616
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 618..622
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 631..634
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 636..638
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 640..643
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 656..660
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 666..672
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 675..678
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 684..687
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 689..691
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 693..696
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 698..713
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 717..721
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 727..730
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 733..735
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 742..745
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 749..755
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 761..763
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 765..770
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 772..774
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 780..788
FT /evidence="ECO:0007829|PDB:7EY9"
SQ SEQUENCE 794 AA; 89396 MW; C55E87879B266F4D CRC64;
MALISQSIKN LKGGISQQPD ILRYPDQGSR QVNGWSSETE GLQKRPPLVF LNTLGDNGAL
GQAPYIHLIN RDEHEQYYAV FTGSGIRVFD LSGNEKQVRY PNGSNYIKTA NPRNDLRMVT
VADYTFIVNR NVVAQKNTKS VNLPNYNPNQ DGLINVRGGQ YGRELIVHIN GKDVAKYKIP
DGSQPEHVNN TDAQWLAEEL AKQMRTNLSD WTVNVGQGFI HVTAPSGQQI DSFTTKDGYA
DQLINPVTHY AQSFSKLPPN APNGYMVKIV GDASKSADQY YVRYDAERKV WTETLGWNTE
DQVLWETMPH ALVRAADGNF DFKWLEWSPK SCGDVDTNPW PSFVGSSIND VFFFRNRLGF
LSGENIILSR TAKYFNFYPA SIANLSDDDP IDVAVSTNRI AILKYAVPFS EELLIWSDEA
QFVLTASGTL TSKSVELNLT TQFDVQDRAR PFGIGRNVYF ASPRSSFTSI HRYYAVQDVS
SVKNAEDITS HVPNYIPNGV FSICGSGTEN FCSVLSHGDP SKIFMYKFLY LNEELRQQSW
SHWDFGENVQ VLACQSISSD MYVILRNEFN TFLARISFTK NAIDLQGEPY RAFMDMKIRY
TIPSGTYNDD TFTTSIHIPT IYGANFGRGK ITVLEPDGKI TVFEQPTAGW NSDPWLRLSG
NLEGRMVYIG FNINFVYEFS KFLIKQTADD GSTSTEDIGR LQLRRAWVNY ENSGTFDIYV
ENQSSNWKYT MAGARLGSNT LRAGRLNLGT GQYRFPVVGN AKFNTVYILS DETTPLNIIG
CGWEGNYLRR SSGI
