TUBE_BPLP2
ID TUBE_BPLP2 Reviewed; 301 AA.
AC Q9MCC1;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 12-AUG-2020, entry version 38.
DE RecName: Full=Tail tube protein {ECO:0000303|PubMed:24027307};
DE Short=TTP {ECO:0000305};
DE AltName: Full=Gene product 11 {ECO:0000305};
DE Short=gp11 {ECO:0000305};
DE AltName: Full=Major tail protein {ECO:0000303|PubMed:24027307};
DE Short=MTP {ECO:0000303|PubMed:24027307};
OS Lactococcus phage p2 (Lactococcus lactis bacteriophage p2).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Siphoviridae; Skunavirus.
OX NCBI_TaxID=254252;
OH NCBI_TaxID=1358; Lactococcus lactis.
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tremblay D.M., Deveau H., Moineau S.;
RT "Complete genomic sequence of Lactococcus lactis phage p2.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=22820334; DOI=10.1128/aem.01755-12;
RA Labrie S.J., Tremblay D.M., Moisan M., Villion M., Magadan A.H.,
RA Campanacci V., Cambillau C., Moineau S.;
RT "Involvement of the major capsid protein and two early-expressed phage
RT genes in the activity of the lactococcal abortive infection mechanism
RT AbiT.";
RL Appl. Environ. Microbiol. 78:6890-6899(2012).
RN [3]
RP STRUCTURE BY ELECTRON MICROSCOPY (22 ANGSTROMS) OF THE TAIL, FUNCTION,
RP SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH THE TAIL TERMINATOR
RP PROTEIN, AND DOMAIN.
RX PubMed=24027307; DOI=10.1128/jvi.02033-13;
RA Bebeacua C., Tremblay D., Farenc C., Chapot-Chartier M.P., Sadovskaya I.,
RA van Heel M., Veesler D., Moineau S., Cambillau C.;
RT "Structure, adsorption to host, and infection mechanism of virulent
RT lactococcal phage p2.";
RL J. Virol. 87:12302-12312(2013).
CC -!- FUNCTION: Forms the cylindrical rigid tail tube with a 4 nm wide
CC central channel for DNA ejection. The tube is composed of 31 hexameric
CC rings. {ECO:0000269|PubMed:24027307}.
CC -!- SUBUNIT: Homohexamer. Interacts with the tail terminator protein.
CC {ECO:0000269|PubMed:24027307}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:22820334,
CC ECO:0000269|PubMed:24027307}. Note=Constitutes the tail tube.
CC {ECO:0000269|PubMed:22820334, ECO:0000269|PubMed:24027307}.
CC -!- DOMAIN: The C-terminus probably makes protruding decorations on the
CC whole length of the tail tube. {ECO:0000269|PubMed:24027307}.
CC -!- SIMILARITY: Belongs to the skunalikevirus tail tube protein family.
CC {ECO:0000305}.
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DR EMBL; GQ979703; AAF85633.1; -; Genomic_DNA.
DR ABCD; Q9MCC1; 1 sequenced antibody.
DR Proteomes; UP000002348; Genome.
DR GO; GO:0098026; C:virus tail, tube; IDA:UniProtKB.
DR GO; GO:0099001; P:viral genome ejection through host cell envelope, long flexible tail mechanism; IEA:UniProtKB-KW.
DR InterPro; IPR010517; L_lac_phage_MSP.
DR Pfam; PF06488; L_lac_phage_MSP; 1.
DR PIRSF; PIRSF004357; L_lac_phage_MSP; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Viral genome ejection through host cell envelope;
KW Viral long flexible tail ejection system;
KW Viral penetration into host cytoplasm; Viral tail protein;
KW Viral tail tube protein; Virion; Virus entry into host cell.
FT CHAIN 1..301
FT /note="Tail tube protein"
FT /id="PRO_0000438223"
SQ SEQUENCE 301 AA; 32394 MW; DADCCE7510224AE8 CRC64;
MKLDYNSREI FFGNEALIVA DMTKGSNGKP EFTNHKIVTG LVSVGSMEDQ AETNSYPADD
VPDHGVKKGA TLLQGEMVFI QTDQALKEDM LGQQRTENGL GWSPTGNWKT KCVQYLIKGR
KRDKVTGEFV DGYRVVVYPH LTPTAEATKE SETDSVDGVD PIQWTLAVQA TESDIYSNGG
KKVPAIEYEI WGEQAKDFAK KMESGLFIMQ PDTVLAGAIT LVAPVIPNVT TATKGNNDGT
IVVPDTLKDS KGGTVKVTSV IKDAHGKVAT NGQLAPGVYI VTFSADGYED VTAGVSVTDH
S
