ID   TUBE_BPMU               Reviewed;         118 AA.
AC   P79679;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   23-FEB-2022, entry version 63.
DE   RecName: Full=Tail tube protein;
DE            Short=TTP;
DE   AltName: Full=Gene product 40;
DE            Short=gp40;
DE   AltName: Full=Gene product M;
DE            Short=gpM;
GN   Name=M; OrderedLocusNames=Mup40;
OS   Escherichia phage Mu (Bacteriophage Mu).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Muvirus.
OX   NCBI_TaxID=10677;
OH   NCBI_TaxID=543; Enterobacteriaceae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PROTEIN SEQUENCE OF 2-11.
RX   PubMed=9714755; DOI=10.1016/s0167-4781(98)00102-x;
RA   Takeda S., Sasaki T., Ritani A., Howe M.M., Arisaka F.;
RT   "Discovery of the tail tube gene of bacteriophage Mu and sequence analysis
RT   of the sheath and tube genes.";
RL   Biochim. Biophys. Acta 1399:88-92(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11922669; DOI=10.1006/jmbi.2002.5437;
RA   Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.;
RT   "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like
RT   prophages in Haemophilus, Neisseria and Deinococcus.";
RL   J. Mol. Biol. 317:337-359(2002).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=3904174; DOI=10.1016/0042-6822(85)90388-5;
RA   Grundy F.J., Howe M.M.;
RT   "Morphogenetic structures present in lysates of amber mutants of
RT   bacteriophage Mu.";
RL   Virology 143:485-504(1985).
RN   [4]
RP   INDUCTION.
RX   PubMed=8293968; DOI=10.1093/genetics/135.3.619;
RA   Chiang L.W., Howe M.M.;
RT   "Mutational analysis of a C-dependent late promoter of bacteriophage Mu.";
RL   Genetics 135:619-629(1993).
RN   [5]
RP   REVIEW.
RX   PubMed=22297511; DOI=10.1007/978-1-4614-0980-9_5;
RA   Leiman P.G., Shneider M.M.;
RT   "Contractile tail machines of bacteriophages.";
RL   Adv. Exp. Med. Biol. 726:93-114(2012).
CC   -!- FUNCTION: Polymerizes to make up the central tail tube that is
CC       surrounded by the tail sheath protein (TSP). Tail tube protein
CC       polymerization takes place around the tape measure protein (TMP) and is
CC       probably directed by chaperone proteins. Upon binding to host cell, the
CC       tail sheath contracts and the tail tube penetrates the host envelope.
CC       The tail tube is involved in viral genome delivery during ejection.
CC       {ECO:0000269|PubMed:9714755}.
CC   -!- SUBUNIT: Homomultimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm
CC       {ECO:0000305}. Note=Tail. {ECO:0000305}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       Expression of late genes is activated by the viral late transcription
CC       activator C. {ECO:0000269|PubMed:8293968}.
CC   -!- DISRUPTION PHENOTYPE: No tail is synthesized.
CC       {ECO:0000269|PubMed:3904174}.
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DR   EMBL; AB000833; BAA19196.1; -; Genomic_DNA.
DR   EMBL; AF083977; AAF01118.1; -; Genomic_DNA.
DR   RefSeq; NP_050644.1; NC_000929.1.
DR   GeneID; 2636260; -.
DR   KEGG; vg:2636260; -.
DR   Proteomes; UP000002611; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0098026; C:virus tail, tube; IDA:UniProtKB.
DR   GO; GO:0099000; P:viral genome ejection through host cell envelope, contractile tail mechanism; IEA:UniProtKB-KW.
DR   InterPro; IPR019596; Phage_Mu_GpM_tail_tub.
DR   Pfam; PF10618; Tail_tube; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Host cytoplasm; Late protein;
KW   Reference proteome; Viral contractile tail ejection system;
KW   Viral genome ejection through host cell envelope;
KW   Viral penetration into host cytoplasm; Viral tail protein;
KW   Viral tail tube protein; Virion; Virus entry into host cell.
FT   INIT_MET        1
FT                   /note="Removed; by host"
FT                   /evidence="ECO:0000269|PubMed:9714755"
FT   CHAIN           2..118
FT                   /note="Tail tube protein"
FT                   /id="PRO_0000077688"
SQ   SEQUENCE   118 AA;  12828 MW;  375A6934BDDD22CB CRC64;
     MAGNQRQGVA FIRVNGMELE SMEGASFTPS GITREEVTGS RVYGWKGKPR AAKVECKIPG
     GGPIGLDEII DWENITVEFQ ADTGETWMLA NAWQADEPKN DGGEISLVLM AKQSKRIA