TUBE_DROVI
ID TUBE_DROVI Reviewed; 514 AA.
AC Q08171;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Protein Tube;
GN Name=tub; Synonyms=tube;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8253071; DOI=10.1002/j.1460-2075.1993.tb06019.x;
RA Letsou A., Alexander S., Wasserman S.A.;
RT "Domain mapping of tube, a protein essential for dorsoventral patterning of
RT the Drosophila embryo.";
RL EMBO J. 12:3449-3458(1993).
CC -!- FUNCTION: Required for the determination of embryonic dorsoventral
CC polarity. Is involved in transduction of information regulating nuclear
CC import of dorsal protein.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Maternal and zygotic gene product.
CC -!- DEVELOPMENTAL STAGE: Expressed maximally early in embryogenesis, and in
CC late larval development.
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DR EMBL; L20449; AAA28995.1; -; Genomic_DNA.
DR AlphaFoldDB; Q08171; -.
DR SMR; Q08171; -.
DR STRING; 7244.FBpp0237381; -.
DR PRIDE; Q08171; -.
DR eggNOG; ENOG502S7SQ; Eukaryota.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0019904; F:protein domain specific binding; IEA:EnsemblMetazoa.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IEA:EnsemblMetazoa.
DR GO; GO:0048262; P:determination of dorsal/ventral asymmetry; IEA:EnsemblMetazoa.
DR GO; GO:0045087; P:innate immune response; IEA:EnsemblMetazoa.
DR GO; GO:0007526; P:larval somatic muscle development; IEA:EnsemblMetazoa.
DR GO; GO:0002804; P:positive regulation of antifungal peptide production; IEA:EnsemblMetazoa.
DR GO; GO:0008063; P:Toll signaling pathway; IEA:EnsemblMetazoa.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR029397; Tube_Death.
DR Pfam; PF14786; Death_2; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Repeat; Transducer.
FT CHAIN 1..514
FT /note="Protein Tube"
FT /id="PRO_0000065695"
FT REGION 226..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..460
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 54541 MW; D8DE8A0F8019E699 CRC64;
MEMAKANGWA VVCTSTNTNT VPIYSKYTRC TELRRVDDND IYKLATILDV NGCWRKLMSI
IPKRLDAQAC SAPGALNYQE IAAKVGLKYT AQQISLIDGT AERLTPGQSI SQVMIDEWKT
SGKLNERPTV GVLLQLLVHA EIYSAADFVA LHFLNEPKPE RPTDGPAAHI SLDLCSEDLS
EDMDVEDGAS YQPNTSALNA AVEQARGTGM NLDYFDKHMV RRDKSVPQQL ENGTSSTVPV
PPPRAARSSR LLKATASNVA PTTASNAPSA SNTANVPNLS ILNASSKKLA ASSEQTLQPQ
NIPNLSILNG SSEAVLMATT STTLDAGKSD NASNGRSSAS TSTATIPNVP LITLLIENSS
CEISDASDAT QITSKSTATK TVPDMSTASY NNLPAISALN LNIASGAGEL DGNGAKARGD
NADNNSSGTN SLSNDDDEQK EDDDDDDDDD VVDVDDEEAD VSLPNLSNSD HNDSSLTTVT
CTSGENSFEF TNDSSSASND DYTNNIPNLS ELQQ
