TUD_DROME
ID TUD_DROME Reviewed; 2515 AA.
AC P25823; Q9W2J8;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Maternal protein tudor;
GN Name=tud; ORFNames=CG9450;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1936993; DOI=10.1101/gad.5.11.2060;
RA Golumbeski G.S., Bardsley A., Tax F., Boswell R.E.;
RT "Tudor, a posterior-group gene of Drosophila melanogaster, encodes a novel
RT protein and an mRNA localized during mid-oogenesis.";
RL Genes Dev. 5:2060-2070(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP INTERACTION WITH VLS.
RX PubMed=15800004; DOI=10.1242/dev.01809;
RA Anne J., Mechler B.M.;
RT "Valois, a component of the nuage and pole plasm, is involved in assembly
RT of these structures, and binds to Tudor and the methyltransferase
RT Capsuleen.";
RL Development 132:2167-2177(2005).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226; SER-235; SER-239 AND
RP SER-800, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
RN [6]
RP INTERACTION WITH ME31B.
RX PubMed=28945271; DOI=10.1002/1873-3468.12854;
RA DeHaan H., McCambridge A., Armstrong B., Cruse C., Solanki D.,
RA Trinidad J.C., Arkov A.L., Gao M.;
RT "An in vivo proteomic analysis of the Me31B interactome in Drosophila germ
RT granules.";
RL FEBS Lett. 591:3536-3547(2017).
CC -!- FUNCTION: Required during oogenesis for the formation of primordial
CC germ cells and for normal abdominal segmentation.
CC -!- SUBUNIT: Interacts with vls (PubMed:15800004). Interacts with me31B
CC (when dimethylated on Arg residues) (PubMed:28945271).
CC {ECO:0000269|PubMed:15800004, ECO:0000269|PubMed:28945271}.
CC -!- INTERACTION:
CC P25823; Q7PLK0: AGO3; NbExp=5; IntAct=EBI-498741, EBI-3431981;
CC P25823; O76922: aub; NbExp=7; IntAct=EBI-498741, EBI-98862;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28945271}.
CC Note=Detected in the germ plasm of occytes and in the nuage of nurse
CC cells. {ECO:0000269|PubMed:28945271}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the life cycle.
CC -!- MISCELLANEOUS: The TUD mRNA accumulates within the posterior region of
CC the developing oocyte during the early to middle stages of oogenesis.
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DR EMBL; X62420; CAA44286.1; -; mRNA.
DR EMBL; AE013599; AAF46693.1; -; Genomic_DNA.
DR PIR; A41519; A41519.
DR RefSeq; NP_476773.1; NM_057425.3.
DR PDB; 3NTH; X-ray; 2.80 A; A=2344-2515.
DR PDB; 3NTI; X-ray; 2.80 A; A=2344-2515.
DR PDB; 3NTK; X-ray; 1.80 A; A/B=2346-2514.
DR PDB; 4Q5W; X-ray; 1.80 A; A/B=1978-2160.
DR PDB; 4Q5Y; X-ray; 3.00 A; A=2164-2515.
DR PDBsum; 3NTH; -.
DR PDBsum; 3NTI; -.
DR PDBsum; 3NTK; -.
DR PDBsum; 4Q5W; -.
DR PDBsum; 4Q5Y; -.
DR AlphaFoldDB; P25823; -.
DR SMR; P25823; -.
DR BioGRID; 63051; 17.
DR ComplexPortal; CPX-3181; aubergine-tudor complex.
DR IntAct; P25823; 4.
DR MINT; P25823; -.
DR STRING; 7227.FBpp0071508; -.
DR iPTMnet; P25823; -.
DR PaxDb; P25823; -.
DR PRIDE; P25823; -.
DR EnsemblMetazoa; FBtr0071582; FBpp0071508; FBgn0003891.
DR GeneID; 37417; -.
DR KEGG; dme:Dmel_CG9450; -.
DR UCSC; CG9450-RA; d. melanogaster.
DR CTD; 37417; -.
DR FlyBase; FBgn0003891; tud.
DR VEuPathDB; VectorBase:FBgn0003891; -.
DR eggNOG; KOG2039; Eukaryota.
DR GeneTree; ENSGT00940000171066; -.
DR InParanoid; P25823; -.
DR OrthoDB; 496838at2759; -.
DR PhylomeDB; P25823; -.
DR SignaLink; P25823; -.
DR BioGRID-ORCS; 37417; 1 hit in 3 CRISPR screens.
DR ChiTaRS; tud; fly.
DR EvolutionaryTrace; P25823; -.
DR GenomeRNAi; 37417; -.
DR PRO; PR:P25823; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0003891; Expressed in oviduct (Drosophila) and 26 other tissues.
DR ExpressionAtlas; P25823; baseline and differential.
DR Genevisible; P25823; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0043186; C:P granule; IDA:FlyBase.
DR GO; GO:0045495; C:pole plasm; IDA:FlyBase.
DR GO; GO:0007281; P:germ cell development; IMP:FlyBase.
DR GO; GO:0008298; P:intracellular mRNA localization; TAS:FlyBase.
DR GO; GO:0048477; P:oogenesis; IDA:ComplexPortal.
DR GO; GO:1903863; P:P granule assembly; IDA:ComplexPortal.
DR GO; GO:0030719; P:P granule organization; IMP:FlyBase.
DR GO; GO:0034587; P:piRNA metabolic process; IBA:GO_Central.
DR GO; GO:0007277; P:pole cell development; IDA:ComplexPortal.
DR GO; GO:0007279; P:pole cell formation; IDA:ComplexPortal.
DR GO; GO:0007315; P:pole plasm assembly; IMP:FlyBase.
DR GO; GO:1900370; P:positive regulation of post-transcriptional gene silencing by RNA; IDA:ComplexPortal.
DR CDD; cd04508; TUDOR; 8.
DR Gene3D; 2.40.50.90; -; 3.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF00567; TUDOR; 9.
DR SMART; SM00333; TUDOR; 10.
DR PROSITE; PS50304; TUDOR; 9.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Developmental protein; Differentiation; Oogenesis;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..2515
FT /note="Maternal protein tudor"
FT /id="PRO_0000183160"
FT DOMAIN 455..513
FT /note="Tudor 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 641..696
FT /note="Tudor 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1062..1122
FT /note="Tudor 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1355..1414
FT /note="Tudor 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1662..1718
FT /note="Tudor 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1839..1898
FT /note="Tudor 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 2023..2082
FT /note="Tudor 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 2211..2269
FT /note="Tudor 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 2392..2451
FT /note="Tudor 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT REGION 840..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1515..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..937
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1535..1552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1565..1586
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 226
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 235
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 239
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 800
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 116
FT /note="K -> N (in Ref. 1; CAA44286)"
FT /evidence="ECO:0000305"
FT CONFLICT 635..638
FT /note="NQRV -> TREF (in Ref. 1; CAA44286)"
FT /evidence="ECO:0000305"
FT CONFLICT 1763
FT /note="Y -> I (in Ref. 1; CAA44286)"
FT /evidence="ECO:0000305"
FT STRAND 1982..1990
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 1993..1998
FT /evidence="ECO:0007829|PDB:4Q5W"
FT HELIX 1999..2001
FT /evidence="ECO:0007829|PDB:4Q5W"
FT HELIX 2002..2014
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2029..2033
FT /evidence="ECO:0007829|PDB:4Q5W"
FT TURN 2035..2037
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2040..2048
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2054..2058
FT /evidence="ECO:0007829|PDB:4Q5W"
FT TURN 2059..2061
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2064..2068
FT /evidence="ECO:0007829|PDB:4Q5W"
FT HELIX 2075..2077
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2085..2089
FT /evidence="ECO:0007829|PDB:4Q5W"
FT HELIX 2093..2097
FT /evidence="ECO:0007829|PDB:4Q5W"
FT HELIX 2099..2111
FT /evidence="ECO:0007829|PDB:4Q5W"
FT TURN 2112..2115
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2116..2123
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2126..2128
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2130..2137
FT /evidence="ECO:0007829|PDB:4Q5W"
FT HELIX 2143..2159
FT /evidence="ECO:0007829|PDB:4Q5W"
FT STRAND 2164..2174
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2177..2182
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT HELIX 2183..2185
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT HELIX 2186..2194
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2217..2220
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT TURN 2221..2224
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2225..2228
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2231..2234
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2241..2244
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT TURN 2246..2248
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2251..2255
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT TURN 2262..2266
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2272..2277
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT HELIX 2285..2297
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2304..2309
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2318..2324
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT HELIX 2329..2337
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT HELIX 2344..2347
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2349..2358
FT /evidence="ECO:0007829|PDB:3NTK"
FT STRAND 2361..2366
FT /evidence="ECO:0007829|PDB:3NTK"
FT HELIX 2367..2369
FT /evidence="ECO:0007829|PDB:3NTK"
FT HELIX 2370..2383
FT /evidence="ECO:0007829|PDB:3NTK"
FT HELIX 2384..2386
FT /evidence="ECO:0007829|PDB:3NTK"
FT STRAND 2398..2402
FT /evidence="ECO:0007829|PDB:3NTK"
FT TURN 2404..2406
FT /evidence="ECO:0007829|PDB:3NTK"
FT STRAND 2409..2417
FT /evidence="ECO:0007829|PDB:3NTK"
FT STRAND 2419..2421
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2423..2426
FT /evidence="ECO:0007829|PDB:3NTK"
FT TURN 2428..2430
FT /evidence="ECO:0007829|PDB:3NTK"
FT STRAND 2433..2437
FT /evidence="ECO:0007829|PDB:3NTK"
FT HELIX 2444..2447
FT /evidence="ECO:0007829|PDB:3NTK"
FT STRAND 2452..2458
FT /evidence="ECO:0007829|PDB:3NTK"
FT HELIX 2460..2462
FT /evidence="ECO:0007829|PDB:3NTK"
FT HELIX 2465..2476
FT /evidence="ECO:0007829|PDB:3NTK"
FT TURN 2477..2480
FT /evidence="ECO:0007829|PDB:3NTK"
FT STRAND 2481..2490
FT /evidence="ECO:0007829|PDB:3NTK"
FT STRAND 2492..2494
FT /evidence="ECO:0007829|PDB:4Q5Y"
FT STRAND 2496..2502
FT /evidence="ECO:0007829|PDB:3NTK"
FT HELIX 2507..2510
FT /evidence="ECO:0007829|PDB:3NTK"
FT TURN 2512..2514
FT /evidence="ECO:0007829|PDB:4Q5Y"
SQ SEQUENCE 2515 AA; 285267 MW; 1218700174D66701 CRC64;
MNGQARIALP SKVDLYITHV DHVGPYLKVY GHVNRDAASL ISERIRNLLP TCFAIEPSWS
VERQQALLIP GTFCIFKNIN GPAPGDVEYR RIRVVSADLE GQSMRAEIDF VDFGYKRTVD
SHDLMFPKQP KLLQNIPLHC FQYIVLGICS EWDQTDLAEV RRLVVNQIVK ITVEPTQICD
QKFASLRWKD FELNEFLVQQ KQIGVSVDKQ LMMDHCKKLW KDNPQSPVTE YNNNSIHNSK
TPMEIAREQL AVRQSLAARL DAQRSVQVTP SRPLNADAPD YTPKHLPLVN VTNVQVQMPG
LNNTQKPVFV STNPYNRANY QPAVPAAQPY VPKANPRSQY TYYNVRMNKP INAMPPPAGP
HVPIQHFNQQ ANNVSLSYVP ARFTPPPTPS IAQHQIPIPA FRTTSLTVGL TYDVVISYVE
NGPYLFWVHL KSSDHDLSTM MGQIERTKLK ALAQAPELGT ACVARFSEDG HLYRAMVCAV
YAQRYRVVYV DYGNSELLSA SDLFQIPPEL LEIKPFAFRF ALAGTKEIEP IDDSMKRIFK
KSAIYRNFEL TVQAPESVGS MQTCHLNQNG TNMLELLRQL KNSRQSYKKA EQLENDDAVE
IRFIDSPSNF YVQKVANIGK FEQLMDEMFS YYNANQRVPD QLILGAPCIV KCDQEWYRAE
ILRVDDSVIV RHVDFGYEQN VKRHLIGHIA EKHLEMPRQA IKCCLKGFEN SELSEDKITD
QFEMLAEESN IRRRTFSVRI FRIEPDGLNV VNLLAKNLNV MKKLYKLSMP FEQYLSLEKG
QFNANNTRAE SVISSELNKS HILNSTSIGE TENRLQEQEK EQQQKKVDVR QQQLAVEIPQ
AVKSVSGSKN STDWDKRSST SAGSKDSKRQ QQQQIQRIDR HLDFSCETQS TGSYSSGMSS
PRKGNRQQNG RTPIQSPRHN EKQEAKKNAR FSNSESPRRS RDGQQGNQRS QNAPQGYAQK
PQRQKSTLDG NISSKRSSGV GSDIASSSSE SVAAAKPEKY VSLDKPYALQ EMKTPSKEAA
SLSWWLSPFQ FYIVPKSVSA KYDNIMRDMR EFYRQKQHQP LQLKVGSTVV VRQRKDNAIL
RATVTACNHM MRKYRVFCVD TGSLITVTSE DIWQLEQRFA DPPCMAHRCS FHSVVTNYDP
LYIVDRMETF VPVNAKVDCE FVSKEKSNQG SNTSSTCSYT VNIFVNGASL RDMLVKAEFL
TEVAPEIRVN LLAGQQIRGK FTSIRDMTSF KVQFDYGNNV NFLCTYDDAK FVKSNPNLAR
RFKEFYEGKS FALNVKNVCE NNIVHLRPVM PLFMEDRRSF ICPYPVVLSS FQALVVYTAK
PYRVYVQPQA IVPSMQTLLD NMYEHYKAKG DSLKKFDVGQ ICAVRSSDGN WYRARISGKD
SNAACFEVFY IDYGNTEEIK RDDIKALDAK FYEHASGFAV EINLPIGRPS NDTKLKARIS
EILEEKVVTI KSIEVRRSHL IADVILENNQ SVIDLLKAEK LVPGKDLDYM RKQMEKGKSR
TYEYIETVDL TLDEEEDKGR KETVSKSGSA NASPKKKQHN DKDREPKKSK PAEPARTVAP
QPVALKTPSP VPAEPAPVPK PATPVPEVVE VPEINPTVRE AAAESKQAPA QEDPYKDLDC
VVLSHCDNPA QFYVHPIDQL SKLNQLHENL QIVSPSLPQL MNVVNGADCV SMYSVDKCWY
RAKIIDAELM VLLFIDYGNT DCVSDATDIK ESMWSHIEPF CLPCALPIRP KGTADWVDAA
NGIFNESYSK VPRLEYLTQG DHYTTSYVNM YIDGEDVAKK LIADGFARPL EYLASGCSCY
ISHVNGICDF FIQLERDSKA LELIELYLRK KDTLKPLEGF EKGLIVAALF EDDELWYRAQ
LQKELPDSRY EVLFIDYGNT STTSKCLMLS EEIASLPSLS KKCSLQLPDA YISWSPEAEA
KFAELTGEGE LVFTTQLLKP GQDHVTIDLL LDGENIIDRL LPLCQRKEPK EASKESLAVT
TKAIITHVEN TSRIYLQFSE KDSLMDIICE KLNGSKLQPK TEKAAVDDMC VVQFADDLEF
YRSRILEVLE DDQYKVILID YGNTTVVDKL YELPQEFTLI KPVAEICSME PSAIFEKNKA
LTLTTFDALL DSCKGVVAVE FVNKSASPPV VRLTTKDKRS LKIYEHLQKL VQAELKLIQK
RNENSECIIS YGNSPKSFYV QMKHNSADLD LIVKTLQSLK KEKLKKLIDP TTNSNGVCYS
QEDACYYRCS IKSVLDPSQG FEVFLLDYGN TLVVPEVWQL PQEIEPIPSL ALHCQLSKIP
MDVSDEKLEE AFAALLEQHF GELYEITTQP NEDETKPLIA ELRINYKDFV QELVSTVTGV
QKPLEAELHN CVVVQFDGPM SFYVQMESDV PALEQMTDKL LDAEQDLPAF SDLKEGALCV
AQFPEDEVFY RAQIRKVLDD GKCEVHFIDF GNNAVTQQFR QLPEELAKPA RYSRHCELDA
STISKCDAAL LQSFIDTRFS ETFQVEILAT KGTGTHVVRL FYQSKNISEK LQECQ
