ID   TUFT1_PIG               Reviewed;         188 AA.
AC   O97557;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Tuftelin;
DE   Flags: Fragment;
GN   Name=TUFT1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tooth;
RX   PubMed=9839784; DOI=10.1177/00220345980770120401;
RA   MacDougall M., Simmons D., Dodds A., Knight C., Luan X., Zeichner-David M.,
RA   Zhang C., Ryu O.H., Qian Q., Simmer J.P., Hu C.-C.;
RT   "Cloning, characterization, and tissue expression pattern of mouse tuftelin
RT   cDNA.";
RL   J. Dent. Res. 77:1970-1978(1998).
CC   -!- FUNCTION: Involved in the mineralization and structural organization of
CC       enamel. {ECO:0000250|UniProtKB:P27628}.
CC   -!- SUBUNIT: Interacts with TFIP11. {ECO:0000250|UniProtKB:O08970}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P27628}.
CC       Note=Secreted at a very early stage of enamel formation, and tightly
CC       bound to the surface of the growing crystallites.
CC       {ECO:0000250|UniProtKB:P27628}.
CC   -!- SIMILARITY: Belongs to the tuftelin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF030318; AAD01896.1; -; mRNA.
DR   AlphaFoldDB; O97557; -.
DR   SMR; O97557; -.
DR   PaxDb; O97557; -.
DR   PeptideAtlas; O97557; -.
DR   PRIDE; O97557; -.
DR   eggNOG; ENOG502QW76; Eukaryota.
DR   InParanoid; O97557; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   InterPro; IPR024846; Tuftelin.
DR   PANTHER; PTHR23171:SF4; PTHR23171:SF4; 1.
PE   2: Evidence at transcript level;
KW   Biomineralization; Coiled coil; Reference proteome; Secreted.
FT   CHAIN           <1..>188
FT                   /note="Tuftelin"
FT                   /id="PRO_0000183188"
FT   COILED          1..181
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         188
SQ   SEQUENCE   188 AA;  21960 MW;  C6D147967D14523B CRC64;
     SLRKTVQDLL VQLQEAERQH QSERVDFEAT LSRYQREAEQ SHVALQRAED RVEQKEAEVE
     ELQKRLLGME TEHQALLAKV REGVTALEEL RGKNSDCRAE QEKAANLEKE VAGLREKIHH
     LDDMLKSQQR KVRQMIEQLQ NSKTVIQSKD TAIQELKEKI AYLEAENLEM HDRMEHLIEK
     QISHGNFS