ID   TUFT_HUMAN              Reviewed;           4 AA.
AC   P01858;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   11-DEC-2019, entry version 46.
DE   RecName: Full=Phagocytosis-stimulating peptide;
DE   AltName: Full=Tuftsin;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=4112769; DOI=10.1016/s0006-291x(72)80025-1;
RA   Nishioka K., Constantopoulos A., Satoh P.S., Najjar V.A.;
RT   "The characteristics, isolation and synthesis of the phagocytosis
RT   stimulating peptide tuftsin.";
RL   Biochem. Biophys. Res. Commun. 47:172-179(1972).
RN   [2]
RP   IMMUNOGLOBULIN CLASS.
RX   PubMed=4169272; DOI=10.1021/bi00863a008;
RA   Fidalgo B.V., Najjar V.A.;
RT   "The physiological role of the lymphoid system. VI. The stimulatory effect
RT   of leucophilic gamma globulin (leucokinin) on the phagocytic activity of
RT   human polymorphonuclear leucocyte.";
RL   Biochemistry 6:3386-3392(1967).
CC   -!- MISCELLANEOUS: An IgG (called leucokinin) binds reversibly to the cell
CC       membrane of neutrophils in the blood. Leucokininase on the membrane
CC       releases the active peptide tuftsin from the gamma chain. Tuftsin is
CC       essential for maximum stimulation of the phagocytic activity of
CC       neutrophils.
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DR   PIR; A02147; A02147.
DR   Pharos; P01858; Tdark.
PE   1: Evidence at protein level;
KW   Direct protein sequencing.
FT   PEPTIDE         1..4
FT                   /note="Phagocytosis-stimulating peptide"
FT                   /id="PRO_0000044228"
SQ   SEQUENCE   4 AA;  501 MW;  74176321C0000000 CRC64;
     TKPR