TUG1_HUMAN
ID TUG1_HUMAN Reviewed; 153 AA.
AC A0A6I8PU40;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 07-APR-2021, sequence version 2.
DT 03-AUG-2022, entry version 8.
DE RecName: Full=Taurine up-regulated 1 protein {ECO:0000305};
DE Flags: Precursor;
GN Name=TUG1 {ECO:0000312|HGNC:HGNC:26066};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP SUBCELLULAR LOCATION, AND CAUTION.
RX PubMed=31155234; DOI=10.1016/j.cell.2019.05.010;
RA van Heesch S., Witte F., Schneider-Lunitz V., Schulz J.F., Adami E.,
RA Faber A.B., Kirchner M., Maatz H., Blachut S., Sandmann C.L., Kanda M.,
RA Worth C.L., Schafer S., Calviello L., Merriott R., Patone G., Hummel O.,
RA Wyler E., Obermayer B., Muecke M.B., Lindberg E.L., Trnka F., Memczak S.,
RA Schilling M., Felkin L.E., Barton P.J.R., Quaife N.M., Vanezis K.,
RA Diecke S., Mukai M., Mah N., Oh S.J., Kurtz A., Schramm C., Schwinge D.,
RA Sebode M., Harakalova M., Asselbergs F.W., Vink A., de Weger R.A.,
RA Viswanathan S., Widjaja A.A., Gaertner-Rommel A., Milting H.,
RA Dos Remedios C., Knosalla C., Mertins P., Landthaler M., Vingron M.,
RA Linke W.A., Seidman J.G., Seidman C.E., Rajewsky N., Ohler U., Cook S.A.,
RA Hubner N.;
RT "The Translational Landscape of the Human Heart.";
RL Cell 178:242-260.e29(2019).
RN [3]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=32894169; DOI=10.1186/s13059-020-02081-5;
RA Lewandowski J.P., Dumbovic G., Watson A.R., Hwang T., Jacobs-Palmer E.,
RA Chang N., Much C., Turner K.M., Kirby C., Rubinstein N.D., Groff A.F.,
RA Liapis S.C., Gerhardinger C., Bester A., Pandolfi P.P., Clohessy J.G.,
RA Hoekstra H.E., Sauvageau M., Rinn J.L.;
RT "The Tug1 lncRNA locus is essential for male fertility.";
RL Genome Biol. 21:R237.1-R237.35(2020).
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:32894169,
CC ECO:0000305|PubMed:31155234}; Single-pass type I membrane protein
CC {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:32894169};
CC Single-pass type I membrane protein {ECO:0000255}. Cytoplasm
CC {ECO:0000269|PubMed:32894169}.
CC -!- TISSUE SPECIFICITY: Ubiquitous (PubMed:32894169). Highly expressed in
CC testis (PubMed:32894169). {ECO:0000269|PubMed:32894169}.
CC -!- CAUTION: This sequence initiates at a non-canonical CTG leucine codon.
CC {ECO:0000305|PubMed:31155234}.
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DR EMBL; AC004542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A6I8PU40; -.
DR Ensembl; ENST00000644773.2; ENSP00000501406.2; ENSG00000253352.10.
DR GeneCards; TUG1; -.
DR HGNC; HGNC:26066; TUG1.
DR OpenTargets; ENSG00000253352; -.
DR GeneTree; ENSGT01000000220689; -.
DR OMA; VDRAIGW; -.
DR Proteomes; UP000005640; Chromosome 22.
DR Bgee; ENSG00000253352; Expressed in nipple and 212 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Cytoplasm; Membrane; Mitochondrion; Nucleus; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..153
FT /note="Taurine up-regulated 1 protein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000455053"
FT TOPO_DOM 41..132
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 133..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 153 AA; 16006 MW; 8C759B5F23D19842 CRC64;
MARPPPLPGL VGRRNGRAVD RAIGWRLFLL LWHPALGAQA RPPRRAPGGR WRSRRVFLLV
RRTRAAAYAF AIRRGVVRVV GGGGQLLRPA PGEAAAAAAA GFGAAGEAGV AGAGLEAWRH
PSGPARTQLG GQEGAGGWLV VGFLLCLFLL MPP
