TUG1_MOUSE
ID TUG1_MOUSE Reviewed; 142 AA.
AC A0A6I8MX38;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 2.
DT 03-AUG-2022, entry version 7.
DE RecName: Full=Taurine up-regulated 1 protein {ECO:0000305};
DE Flags: Precursor;
GN Name=Tug1 {ECO:0000312|MGI:MGI:2144114};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=32894169; DOI=10.1186/s13059-020-02081-5;
RA Lewandowski J.P., Dumbovic G., Watson A.R., Hwang T., Jacobs-Palmer E.,
RA Chang N., Much C., Turner K.M., Kirby C., Rubinstein N.D., Groff A.F.,
RA Liapis S.C., Gerhardinger C., Bester A., Pandolfi P.P., Clohessy J.G.,
RA Hoekstra H.E., Sauvageau M., Rinn J.L.;
RT "The Tug1 lncRNA locus is essential for male fertility.";
RL Genome Biol. 21:R237.1-R237.35(2020).
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:32894169};
CC Single-pass type I membrane protein {ECO:0000255}. Mitochondrion
CC membrane {ECO:0000250|UniProtKB:A0A6I8PU40}; Single-pass type I
CC membrane protein {ECO:0000255}. Cytoplasm
CC {ECO:0000269|PubMed:32894169}.
CC -!- TISSUE SPECIFICITY: Widely expressed in the adult with highest levels
CC in placenta and testis (PubMed:32894169). Also expressed in a number of
CC embryonic tissues at multiple embryonic stages (PubMed:32894169).
CC {ECO:0000269|PubMed:32894169}.
CC -!- CAUTION: This sequence initiates at a non-canonical CTG leucine codon.
CC {ECO:0000305|PubMed:32894169}.
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DR AlphaFoldDB; A0A6I8MX38; -.
DR MGI; MGI:2144114; Tug1.
DR OMA; VDRAIGW; -.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000056579; Expressed in metanephric loop of Henle and 258 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Cytoplasm; Membrane; Mitochondrion; Nucleus; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..142
FT /note="Taurine up-regulated 1 protein"
FT /evidence="ECO:0000255"
FT /id="PRO_5026021830"
FT TOPO_DOM 41..123
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 124..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 15179 MW; 1D2A6711F3416656 CRC64;
MARPPPLPGL VGRRSGRAVD RAIGWRLFLL LWHPALGAQA RPPRRAPGGR WRSRRVFLLV
RRTRAAAYAF AIRRGVVRVV GGGGQLRPAP GEAAGEAGVA GAGLEAWRHP SGPARTQLEG
QEGAGGWLVV GFLLCLFLLM PP
