ID   TULP_DROER              Reviewed;         448 AA.
AC   B3NJY0;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GG22088;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1] {ECO:0000312|EMBL:EDV55408.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV55408.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CH954179; EDV55408.1; -; Genomic_DNA.
DR   RefSeq; XP_001975008.2; XM_001974972.2.
DR   AlphaFoldDB; B3NJY0; -.
DR   SMR; B3NJY0; -.
DR   STRING; 7220.FBpp0140634; -.
DR   EnsemblMetazoa; FBtr0411847; FBpp0370212; FBgn0114263.
DR   GeneID; 6547821; -.
DR   KEGG; der:6547821; -.
DR   eggNOG; KOG2502; Eukaryota.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   OMA; GYDGPMQ; -.
DR   OrthoDB; 1445357at2759; -.
DR   PhylomeDB; B3NJY0; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein.
FT   CHAIN           1..448
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400836"
FT   REGION          103..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         141
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86PC9"
SQ   SEQUENCE   448 AA;  49881 MW;  1FB87D15E9E7B73E CRC64;
     MNRQLMEAYI RQKRASPGMV QASDLQINRP MSGMRSNSRE LHAYDGPMQF ISSPQNPDQI
     LSNGSPGGIT PVAMNTSRNH SNNMRSLSTI NQEADLIEEI SSHELEDEES SPVTVIEQHQ
     QSASHSANST QSQKPRARQH SFSDNLDEDD YTNRNVAGAA PVRPAGMASS PYKDATLEGS
     SNGTGNGTGG ESEGDVIGNI DQFVMQPAPQ GVLYKCRITR DRKGMDRGLF PIYYLHLERD
     YGKKIFLLGG RKRKKSKTSN YIVSCDPTDL SRNADGFCGK LRSNVFGTSF TVFDNGNKES
     TESPRLDLAV IIYDTNILGF KGPRNMTVIL PGMTEDDQRV KISSADPKQQ GILDLWKMKN
     MDNIVELHNK TPVWNDETQS YVLNFHGRVT QASVKNFQLV HDSDPEYIVM QFGRTSEDVF
     TMDYRYPLCA MQAFAIALSS FDGKIACE