ID   TULP_DROGR              Reviewed;         447 AA.
AC   B4J6R7;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GH20719;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1] {ECO:0000312|EMBL:EDW00970.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDW00970.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CH916367; EDW00970.1; -; Genomic_DNA.
DR   RefSeq; XP_001986103.1; XM_001986067.1.
DR   AlphaFoldDB; B4J6R7; -.
DR   SMR; B4J6R7; -.
DR   STRING; 7222.FBpp0154625; -.
DR   EnsemblMetazoa; FBtr0471657; FBpp0421691; FBgn0128182.
DR   eggNOG; KOG2502; Eukaryota.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   InParanoid; B4J6R7; -.
DR   OMA; GYDGPMQ; -.
DR   OrthoDB; 1445357at2759; -.
DR   PhylomeDB; B4J6R7; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..447
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400837"
FT   REGION          54..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         136
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86PC9"
SQ   SEQUENCE   447 AA;  49539 MW;  ADECAB2F52059092 CRC64;
     MLILRQLMDA YIRQKRASPG MVQASDLQMN RPMSGMRSNS RELHAYDGPM QFIGSPQNPD
     QILSNNSSSI TMNSSRNNSN NMRSLSTINQ EDLIEEISSH ELEDEESSPV TVVEQPIAPQ
     SANSAHSQRA RIGQPSFNDT LDEEDYANRN ISGVAAVRPA GIGSPYKEGA AMEGSNGAAN
     GSGSVGGSGE SEGDVIGQID QFVMQPAPQG VLYKCRITRD RKGMDRGLFP IYYLHLERDY
     GKKIFLLGGR KRKKSKTSNY IVSCDPTDLS RNADGFCGKL RSNVFGTSFT VFDSGNKEST
     DSPRLDLAVI IYDTNILGFK GPRNMTVILP GMTEDDQRVK ISSADPKQQG ILDLWKMKNM
     DNIVELHNKT PVWNDETQSY VLNFHGRVTQ ASVKNFQLVH DSDPEYIVMQ FGRTSEDVFT
     MDYRYPLCAM QAFAIALSSF DGKIACE