ID   TULP_DROPE              Reviewed;         459 AA.
AC   B4H4X0;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GL10151;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1] {ECO:0000312|EMBL:EDW32806.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49 {ECO:0000312|EMBL:EDW32806.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CH479210; EDW32806.1; -; Genomic_DNA.
DR   RefSeq; XP_002025899.1; XM_002025863.1.
DR   AlphaFoldDB; B4H4X0; -.
DR   SMR; B4H4X0; -.
DR   STRING; 7234.FBpp0174258; -.
DR   PRIDE; B4H4X0; -.
DR   EnsemblMetazoa; FBtr0175766; FBpp0174258; FBgn0147761.
DR   GeneID; 6600864; -.
DR   KEGG; dpe:6600864; -.
DR   eggNOG; KOG2502; Eukaryota.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   OMA; GYDGPMQ; -.
DR   PhylomeDB; B4H4X0; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..459
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400840"
FT   REGION          114..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         152
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86PC9"
SQ   SEQUENCE   459 AA;  51024 MW;  026F10919D4154BA CRC64;
     MSAISSRNQK MEQQRQLMEA YIRQKRASPG MVQASDLQIS RPMSGMRSNS RELHAYDGPM
     QFISSPHNPD QILTNGSPVG GTVAMNSTRN HSNNMRTLST ISQEADLIEE ISSHELEDEE
     SSPVTVIEQQ QTAPHSANST HSQRPSTTRQ PSFNDTLDED DYTNRNIAGA APVRPVGLAS
     SPYKEAGLDG SSMETSNGAG GESEGDVIGN IDQFVMQPAP QGVLYKCRIT RDRKGMDRGL
     FPIYYLHLER DYGKKIFLLG GRKRKKSKTS NYIVSCDPTD LSRSADGFCG KLRSNVFGTS
     FTVFDSGNKD STDSPRLDLA VIIYDTNILG FKGPRNMTVI LPGMTEDDQR VKISSADPKQ
     TGILDLYKMK NMDNIVELHN KTPVWNDETQ SYVLNFHGRV TQASVKNFQL VHDSDPEYIV
     MQFGRTSEDV FTMDYRYPLC AMQAFAIALS SFDGKIACE