ID   TULP_DROPS              Reviewed;         456 AA.
AC   Q28X18;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-JUN-2014, sequence version 3.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GA21760;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CM000071; EAL26498.3; -; Genomic_DNA.
DR   AlphaFoldDB; Q28X18; -.
DR   SMR; Q28X18; -.
DR   STRING; 7237.FBpp0306449; -.
DR   eggNOG; KOG2502; Eukaryota.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   InParanoid; Q28X18; -.
DR   OMA; GYDGPMQ; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..456
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400841"
FT   REGION          111..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         149
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   456 AA;  50690 MW;  976E4567ECE9F2B9 CRC64;
     MCKLPFSKSR MRQLMEAYIR QKRASPGMVQ ASDLQISRPM SGMRSNSREL HAYDGPMQFI
     SSPLNPDQIL TNGSPVGGTV AMNSTRNHSN NMRTLSTISQ EADLIEEISS HELEDEESSP
     VTVIEQQQTA PHSANSTHSQ RPSTTRQPSF NDTLDEDDYT NRNIAGAAPV RPVGLASSPY
     KEAGLDGSSM ETSNGAGGES EGDVIGNIDQ FVMQPAPQGV LYKCRITRDR KGMDRGLFPI
     YYLHLERDYG KKIFLLGGRK RKKSKTSNYI VSCDPTDLSR SADGFCGKLR SNVFGTSFTV
     FDSGNKDSTD SPRLDLAVII YDTNILGFKG PRNMTVILPG MTEDDQRVKI SSADPKQTGI
     LDLYKMKNMD NIVELHNKTP VWNDETQSYV LNFHGRVTQA SVKNFQLVHD SDPEYIVMQF
     GRTSEDVFTM DYRYPLCAMQ AFAIALSSFD GKIACE