ID   TULP_DROSE              Reviewed;         443 AA.
AC   B4I7J9;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GM15805;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1] {ECO:0000312|EMBL:EDW56574.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW56574.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CH480824; EDW56574.1; -; Genomic_DNA.
DR   RefSeq; XP_002039709.1; XM_002039673.1.
DR   AlphaFoldDB; B4I7J9; -.
DR   SMR; B4I7J9; -.
DR   STRING; 7238.B4I7J9; -.
DR   EnsemblMetazoa; FBtr0198790; FBpp0197282; FBgn0170721.
DR   GeneID; 6615305; -.
DR   KEGG; dse:6615305; -.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   OMA; GYDGPMQ; -.
DR   PhylomeDB; B4I7J9; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..443
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400842"
FT   REGION          57..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         136
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86PC9"
SQ   SEQUENCE   443 AA;  49232 MW;  7163ED87D8348310 CRC64;
     MEAYIRQKRA SPGMVQASDL QINRPMSGMR SNSRELHAYD GPMQFISSPQ NPDQILTNGS
     PGGINSVAMN TSRNHSNNMR SLSTINQEAD LIEEISSHEL EDEESSPVTV IEQQQQSASH
     SANSTQSQKP RARQHSFSDN LDEDDYTNRN VAGAAPVRPA GMASSPYKDA TLDGSSNGTG
     NGTGGESEGD VIGNIDQFVM QPAPQGVLYK CRITRDRKGM DRGLFPIYYL HLERDYGKKI
     FLLGGRKRKK SKTSNYIVSC DPTDLSRNAD GFCGKLRSNV FGTSFTVFDN GNKESTESPR
     LDLAVIIYDT NILGFKGPRN MTVILPGMTE DDQRVKISSA DPKQQGILDL WKMKNMDNIV
     ELHNKTPVWN DETQSYVLNF HGRVTQASVK NFQLVHDSDP EYIVMQFGRT SEDVFTMDYR
     YPLCAMQAFA IALSSFDGKI ACE