ID   TULP_DROSI              Reviewed;         443 AA.
AC   B4QFM2;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GD11564;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:EDX08014.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CM000362; EDX08014.1; -; Genomic_DNA.
DR   RefSeq; XP_016028825.1; XM_016168622.1.
DR   RefSeq; XP_016028827.1; XM_016168624.1.
DR   AlphaFoldDB; B4QFM2; -.
DR   SMR; B4QFM2; -.
DR   STRING; 7240.B4QFM2; -.
DR   EnsemblMetazoa; FBtr0211474; FBpp0209966; FBgn0183305.
DR   EnsemblMetazoa; FBtr0358083; FBpp0322118; FBgn0183305.
DR   GeneID; 6735490; -.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   OMA; GYDGPMQ; -.
DR   PhylomeDB; B4QFM2; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000000304; Chromosome 2r.
DR   Bgee; FBgn0183305; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..443
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400843"
FT   REGION          57..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         136
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86PC9"
SQ   SEQUENCE   443 AA;  49251 MW;  F0D86B4A8692EEE2 CRC64;
     MEAYIRQKRA SPGMVQASDL QINRPMSGMR SNSRELHAYD GPMQFISSPQ NPDQILTNGS
     PGGINPVAMN TSRNHSNNMR SLSTINQEAD LIEEISSHEL EDEESSPVTV IEQHQQSASH
     SANSTQSQKP RARQHSFSDN LDEDDYTNRN VAGAAPVRPA GMASSPYKDA TLDGSSNGTG
     NGTGGESEGD VIGNIDQFVM QPAPQGVLYK CRITRDRKGM DRGLFPIYYL HLERDYGKKI
     FLLGGRKRKK SKTSNYIVSC DPTDLSRNAD GFCGKLRSNV FGTSFTVFDN GNKESTESPR
     LDLAVIIYDT NILGFKGPRN MTVILPGMTE DDQRVKISSA DPKQQGILDL WKMKNMDNIV
     ELHNKTPVWN DETQSYVLNF HGRVTQASVK NFQLVHDSDP EYIVMQFGRT SEDVFTMDYR
     YPLCAMQAFA IALSSFDGKI ACE