ID   TULP_DROVI              Reviewed;         455 AA.
AC   B4LMR9;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GJ20537;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000312|EMBL:EDW61010.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW61010.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CH940648; EDW61010.1; -; Genomic_DNA.
DR   RefSeq; XP_002049817.2; XM_002049781.2.
DR   RefSeq; XP_015029358.1; XM_015173872.1.
DR   RefSeq; XP_015029359.1; XM_015173873.1.
DR   RefSeq; XP_015029360.1; XM_015173874.1.
DR   AlphaFoldDB; B4LMR9; -.
DR   SMR; B4LMR9; -.
DR   STRING; 7244.FBpp0234954; -.
DR   GeneID; 6625691; -.
DR   KEGG; dvi:6625691; -.
DR   eggNOG; KOG2502; Eukaryota.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   InParanoid; B4LMR9; -.
DR   OMA; GYDGPMQ; -.
DR   PhylomeDB; B4LMR9; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..455
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400844"
FT   REGION          35..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         144
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86PC9"
SQ   SEQUENCE   455 AA;  50506 MW;  A39F55EC94D2C456 CRC64;
     MHPQLHKCRQ LMDAYIRQKR ASPGMVQASD LQMSRPMSGM RGNSRELHAY DGPMQFIGSP
     HNPDQILSNN SSSVHLSSSM NSSRNNSNNL RSLSTINQED LIEEISSHEL EDEESSPVTV
     VENPLPPLSA NSAHSQRLRN GQQSFNETLD EDDYANRNIA GVAPVRPAGI ASPYKDGVAP
     EASNGVANGS NSGVGSAESE GDVIGSIDLF VMQPAPQGVL YKCRITRDRK GMDRGLFPIY
     YLHLERDYGK KIFLLGGRKR KKSKTSNYIV SCDPTDLSRN ADGFCGKLRS NVFGTSFTVF
     DSGNKDSTES PRLDLAVIIY DTNILGFKGP RNMTVILPGM TEDDQRVKIS SADPKQQGIL
     DLWKMKNMDN IVELHNKTPV WNDETQSYVL NFHGRVTQAS VKNFQLVHDS DPEYIVMQFG
     RTSEDVFTMD YRYPLCAMQA FAIALSSFDG KIACE