ID   TULP_DROWI              Reviewed;         451 AA.
AC   B4MKC7;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GK20975;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1] {ECO:0000312|EMBL:EDW72566.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW72566.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CH963846; EDW72566.1; -; Genomic_DNA.
DR   RefSeq; XP_002061580.2; XM_002061544.2.
DR   AlphaFoldDB; B4MKC7; -.
DR   SMR; B4MKC7; -.
DR   STRING; 7260.FBpp0250118; -.
DR   EnsemblMetazoa; FBtr0420011; FBpp0378135; FBgn0222967.
DR   GeneID; 6638331; -.
DR   KEGG; dwi:6638331; -.
DR   eggNOG; KOG2502; Eukaryota.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   InParanoid; B4MKC7; -.
DR   OMA; GYDGPMQ; -.
DR   OrthoDB; 1445357at2759; -.
DR   PhylomeDB; B4MKC7; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..451
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400845"
FT   REGION          113..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         147
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86PC9"
SQ   SEQUENCE   451 AA;  50310 MW;  5AA77ED196C37395 CRC64;
     MPMYLRQLME AYIRQKRASP GMVQASDLQI NRPMSGMRSN SRELHAYDGP MQFMSSPQNP
     DQILTHNSSA TSHISGNNLI SVGGAGSRNN SNNLRTLSTI SQEADLIEEI SSHELEDEES
     SPVPMQEQQK PLPLSANSTR PRTRQQSFSD TLDEDDYANR NIAAAAPVRP AGMAASPYKE
     ANLEGSNGTA NGGESEGDVI GNIDQFVMQP APQGVLYKCR ITRDRKGMDR GLFPIYYLHL
     ERDYGKKIFL LGGRKRKKSK TSNYIVSCDP TDLSRQADGF CGKLRSNVFG TSFTVFDNGN
     KDSTESPRLD LAVIIYDTNI LGFKGPRNMT VILPGMTEDD QRVKISSADP KQQGILDLWK
     LKNMDNIVEL HNKTPVWNDE TQSYVLNFHG RVTQASVKNF QLVHDSDPEY IVMQFGRTSE
     DVFTMDYRYP LCAMQAFAIA LSSFDGKIAC E