ID   TULP_DROYA              Reviewed;         443 AA.
AC   B4P9H8;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Protein king tubby {ECO:0000250|UniProtKB:Q86PC9};
GN   Name=king-tubby {ECO:0000250|UniProtKB:Q86PC9}; ORFNames=GE12168;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000312|EMBL:EDW91298.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW91298.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86PC9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86PC9}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000255}.
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DR   EMBL; CM000158; EDW91298.1; -; Genomic_DNA.
DR   RefSeq; XP_002091586.2; XM_002091550.2.
DR   AlphaFoldDB; B4P9H8; -.
DR   SMR; B4P9H8; -.
DR   STRING; 7245.FBpp0257178; -.
DR   EnsemblMetazoa; FBtr0258686; FBpp0257178; FBgn0229934.
DR   GeneID; 6530695; -.
DR   KEGG; dya:Dyak_GE12168; -.
DR   eggNOG; KOG2502; Eukaryota.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   OMA; GYDGPMQ; -.
DR   OrthoDB; 1445357at2759; -.
DR   PhylomeDB; B4P9H8; -.
DR   ChiTaRS; ktub; fly.
DR   Proteomes; UP000002282; Chromosome 2R.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein.
FT   CHAIN           1..443
FT                   /note="Protein king tubby"
FT                   /id="PRO_0000400846"
FT   REGION          57..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         136
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86PC9"
SQ   SEQUENCE   443 AA;  49234 MW;  5C072F92055CC8BF CRC64;
     MEAYIRQKRA SPGMVQASDL QINRPMSGMR SNSRELHAYD GPMQFISSPQ NPDQILTNGS
     PGGITPVAVN TSRNHSNNMR SLSTINQEAD LIEEISSHEL EDEESSPVTV IEQHQQSASH
     SANSTQSQKP RARQHSFSDN LDEDDYTNRN VAAAAPVRPA GMASSPYKDA TLEGSSNGTG
     NGTGGESEGD VIGNIDQFVM QPAPQGVLYK CRITRDRKGM DRGLFPIYYL HLERDYGKKI
     FLLGGRKRKK SKTSNYIVSC DPTDLSRNAD GFCGKLRSNV FGTSFTVFDN GNKESTESPR
     LDLAVIIYDT NILGFKGPRN MTVILPGMTE DDQRVKISSA DPKQQGILDL WKMKNMDNIV
     ELHNKTPVWN DETQSYVLNF HGRVTQASVK NFQLVHDSDP EYIVMQFGRT SEDVFTMDYR
     YPLCAMQAFA IALSSFDGKI ACE