TUP12_SCHPO
ID TUP12_SCHPO Reviewed; 598 AA.
AC Q9UUG8; O14432;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Transcriptional repressor tup12;
GN Name=tup12; Synonyms=tup1; ORFNames=SPAC630.14c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 38-598.
RC STRAIN=972 / ATCC 24843;
RA Braun B.R.;
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP CHARACTERIZATION.
RX PubMed=10567571; DOI=10.1128/mcb.19.12.8461;
RA Mukai Y., Matsuo E., Roth S.Y., Harashima S.;
RT "Conservation of histone binding and transcriptional repressor functions in
RT a Schizosaccharomyces pombe Tup1p homolog.";
RL Mol. Cell. Biol. 19:8461-8468(1999).
CC -!- FUNCTION: Transcriptional repressor.
CC -!- SIMILARITY: Belongs to the WD repeat TUP1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAB52736.2; -; Genomic_DNA.
DR EMBL; U92792; AAB81475.2; -; mRNA.
DR PIR; T38992; T38992.
DR RefSeq; NP_592910.2; NM_001018310.2.
DR AlphaFoldDB; Q9UUG8; -.
DR SMR; Q9UUG8; -.
DR BioGRID; 279824; 22.
DR STRING; 4896.SPAC630.14c.1; -.
DR iPTMnet; Q9UUG8; -.
DR MaxQB; Q9UUG8; -.
DR PaxDb; Q9UUG8; -.
DR PRIDE; Q9UUG8; -.
DR EnsemblFungi; SPAC630.14c.1; SPAC630.14c.1:pep; SPAC630.14c.
DR GeneID; 2543402; -.
DR KEGG; spo:SPAC630.14c; -.
DR PomBase; SPAC630.14c; tup12.
DR VEuPathDB; FungiDB:SPAC630.14c; -.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_000288_57_23_1; -.
DR InParanoid; Q9UUG8; -.
DR OMA; EHTSVIC; -.
DR PRO; PR:Q9UUG8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0017053; C:transcription repressor complex; EXP:PomBase.
DR GO; GO:0042393; F:histone binding; IDA:PomBase.
DR GO; GO:0003714; F:transcription corepressor activity; IMP:PomBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0061987; P:negative regulation of transcription from RNA polymerase II promoter by glucose; IMP:PomBase.
DR GO; GO:0034396; P:negative regulation of transcription from RNA polymerase II promoter in response to iron; IMP:PomBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR013890; Tscrpt_rep_Tup1_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08581; Tup_N; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..598
FT /note="Transcriptional repressor tup12"
FT /id="PRO_0000051311"
FT REPEAT 285..325
FT /note="WD 1"
FT REPEAT 332..371
FT /note="WD 2"
FT REPEAT 374..413
FT /note="WD 3"
FT REPEAT 415..454
FT /note="WD 4"
FT REPEAT 456..495
FT /note="WD 5"
FT REPEAT 510..549
FT /note="WD 6"
FT REPEAT 552..585
FT /note="WD 7"
FT REGION 118..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 65561 MW; A9E9BAAB05471308 CRC64;
MLFLVISQTT SFMITVRQFT FTIFKFQFMA TSNVSSRVNE LLEAVKKEFE DICQKTKTVE
AQKDDFEYKA MISAQINEMA LMKQTVMDLE MQQSKVKDRY EEEITSLKAQ LEARRKEIAS
GVVPQSSKTK HGRNSVSFGK YGNAGPFNSD NSSKPLILNN GSSGGTPKNL RSPAIDSDGT
VLAPIQTSNV DLGSQYYSSP HVRPAVGATM AGSAMRTFPS NLPLGHPPPP SDSANSSVTP
IAAPLVVNGK VSGNPPYPAE IIPTSNVPNR EEKDWTVTSN VPNKEPPISV QLLHTLEHTS
VICYVRFSAD GKFLATGCNR AAMVFNVETG KLITLLQEES SKREGDLYVR SVAFSPDGKY
LATGVEDQQI RIWDIAQKRV YRLLTGHEQE IYSLDFSKDG KTLVSGSGDR TVCLWDVEAG
EQKLILHTDD GVTTVMFSPD GQFIAAGSLD KVIRIWTSSG TLVEQLHGHE ESVYSVAFSP
DGKYLVSGSL DNTIKLWELQ CVSNVAPSMY KEGGICKQTF TGHKDFILSV TVSPDGKWII
SGSKDRTIQF WSPDSPHSQL TLQGHNNSVI SVAVSPNGHC FATGSGDLRA RIWSYEDL
