ID   TUP1_CANAW              Reviewed;         511 AA.
AC   C4YFX2; P56093; Q5AB65;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Transcriptional repressor TUP1;
GN   Name=TUP1; Synonyms=CHP1; ORFNames=CAWG_01360;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=9204892; DOI=10.1126/science.277.5322.105;
RA   Braun B.R., Johnson A.D.;
RT   "Control of filament formation in Candida albicans by the transcriptional
RT   repressor TUP1.";
RL   Science 277:105-109(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Represses transcription by RNA polymerase II. Represses genes
CC       responsible for initiating filamentous growth and this repression is
CC       lifted under inducing environmental conditions.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB63195.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF005741; AAB63195.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CH672346; EEQ43123.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YFX2; -.
DR   SMR; C4YFX2; -.
DR   STRING; 5476.C4YFX2; -.
DR   EnsemblFungi; EEQ43123; EEQ43123; CAWG_01360.
DR   VEuPathDB; FungiDB:CAWG_01360; -.
DR   HOGENOM; CLU_000288_57_23_1; -.
DR   OMA; EHTSVIC; -.
DR   PHI-base; PHI:211; -.
DR   PHI-base; PHI:6806; -.
DR   Proteomes; UP000001429; Chromosome 1, Supercontig 1.1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001632; Gprotein_B.
DR   InterPro; IPR013890; Tscrpt_rep_Tup1_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF08581; Tup_N; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00319; GPROTEINB.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Repeat; Repressor; Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..511
FT                   /note="Transcriptional repressor TUP1"
FT                   /id="PRO_0000413064"
FT   REPEAT          197..237
FT                   /note="WD 1"
FT   REPEAT          252..293
FT                   /note="WD 2"
FT   REPEAT          294..333
FT                   /note="WD 3"
FT   REPEAT          335..374
FT                   /note="WD 4"
FT   REPEAT          384..423
FT                   /note="WD 5"
FT   REPEAT          431..470
FT                   /note="WD 6"
FT   REPEAT          473..511
FT                   /note="WD 7"
FT   REGION          90..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        113
FT                   /note="Q -> QQ (in Ref. 1; AAB63195)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        120
FT                   /note="V -> A (in Ref. 1; AAB63195)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   511 AA;  57503 MW;  7A7377D80381A354 CRC64;
     MYPQRTQHQQ RLTELLDAIK TEFDYASNEA SSFKKVQEDY DSKYQQQAAE MQQIRQTVYD
     LELAHRKIKE AYEEEILRLK NELDTRDRQM KNGFQQQQQQ QQQQQQQQQQ QQQIVAPPAV
     PPAPPTPVTS LSVIDKSQYI VNPTQRANHV KEIPPFLQDL DIAKANPEFK KQHLEYYVLY
     NPAFSKDLDI DMVHSLDHSS VVCCVRFSRD GKFIATGCNK TTQVFNVTTG ELVAKLIDES
     SNENKDDNTT ASGDLYIRSV CFSPDGKLLA TGAEDKLIRI WDLSTKRIIK ILRGHEQDIY
     SLDFFPDGDR LVSGSGDRSV RIWDLRTSQC SLTLSIEDGV TTVAVSPDGK LIAAGSLDRT
     VRVWDSTTGF LVERLDSGNE NGNGHEDSVY SVAFSNNGEQ IASGSLDRTV KLWHLEGKSD
     KKSTCEVTYI GHKDFVLSVC CTPDNEYILS GSKDRGVIFW DQASGNPLLM LQGHRNSVIS
     VAVSLNSKGT EGIFATGSGD CKARIWKWTK K