TUP1_DICDI
ID TUP1_DICDI Reviewed; 579 AA.
AC O76734; Q54SS6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=General transcriptional corepressor tupA;
GN Name=tupA; Synonyms=tup1; ORFNames=DDB_G0282189;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3;
RA Pfeifer M., Faix J., Gerisch G.;
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Acts as component of the trfA-tupA corepressor complex which
CC is involved in the repression of many genes in a wide variety of
CC physiological processes. May also be involved in the derepression of at
CC least some target genes. The complex is recruited to target genes by
CC interaction with DNA-bound transcriptional repressors. The complex
CC recruits histone deacetylases to produce a repressive chromatin
CC structure, interacts with hypoacetylated N-terminal tails of histones
CC H3 and H4 that have been programmed for repression by the action of
CC histone deacetylases and interferes directly with the transcriptional
CC machinery by associating with the RNA polymerase II mediator complex
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with trfA to form the trfA-tupA corepressor
CC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat TUP1 family. {ECO:0000305}.
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DR EMBL; AF079369; AAC29438.1; -; mRNA.
DR EMBL; AAFI02000046; EAL66300.1; -; Genomic_DNA.
DR RefSeq; XP_640309.1; XM_635217.1.
DR AlphaFoldDB; O76734; -.
DR SMR; O76734; -.
DR STRING; 44689.DDB0214909; -.
DR PaxDb; O76734; -.
DR EnsemblProtists; EAL66300; EAL66300; DDB_G0282189.
DR GeneID; 8623485; -.
DR KEGG; ddi:DDB_G0282189; -.
DR dictyBase; DDB_G0282189; tupA.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_000288_57_23_1; -.
DR InParanoid; O76734; -.
DR OMA; DYYILYN; -.
DR PhylomeDB; O76734; -.
DR PRO; PR:O76734; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013890; Tscrpt_rep_Tup1_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08581; Tup_N; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..579
FT /note="General transcriptional corepressor tupA"
FT /id="PRO_0000327393"
FT REPEAT 279..319
FT /note="WD 1"
FT REPEAT 325..364
FT /note="WD 2"
FT REPEAT 367..406
FT /note="WD 3"
FT REPEAT 413..452
FT /note="WD 4"
FT REPEAT 455..494
FT /note="WD 5"
FT REPEAT 501..540
FT /note="WD 6"
FT REPEAT 543..579
FT /note="WD 7"
FT REGION 83..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 65300 MW; A01D52AEA1F5D7B0 CRC64;
MYGRTARASE LLDNLKGEID ALNHELSLYK HQKDDYERKF QNQLAELNTI QQTLYDLERG
QNKMKIHYEE EIRQLKRQLE QQNINASQRD LNSPSTFRSN SPAPPAQHNN NNNNIINNNN
NNNNNNNNMQ RNTPTPTIPD KGQPKQRQRS GSGEFYQQPG LGPQQLNFQQ LNLQQQQQQL
QQQQQQGSGQ SFPSLSPLDS NRHPKEMGNN MSGNSMSMNN NNNNLNKKPD MEEVKEEDRR
RHDTEMSEEN GKEKGTDWLV GYNPSVQTNL NIDLLHNLQH NSVVCCVNFS NDGKYLATGC
NRSAQIYDVD TGKKVHAFVD ESEKDGDLYI RSVCFSPDGN YLATGAEDKT VKVWDIHTKK
IQHTFYGHEL DIYSLDYSSD GRFIVSGSGD KKAKIWDIEK GKCAFTLGNE EVGPKNGVTS
VAMSPDGRLV AAGSLDNIVR LWDAQTGYFL ERYEGHLDSV YSVAFSPDGK SLASGSLDKS
LKLWDLSGSR SRSRCRATFN GHKDFVLSVA FSPDGSWLIS GSKDRSVQFW DPRNGTTHMM
LQGHKNSVIS VALSPKNNSH GVFATGSGDF RSRLWKYDS
