ID   TUP1_KLULA              Reviewed;         682 AA.
AC   P56094; Q6CKJ2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=General transcriptional corepressor TUP1;
GN   Name=TUP1; OrderedLocusNames=KLLA0F10263g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Braun B.R., Johnson A.D.;
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=10567571; DOI=10.1128/mcb.19.12.8461;
RA   Mukai Y., Matsuo E., Roth S.Y., Harashima S.;
RT   "Conservation of histone binding and transcriptional repressor functions in
RT   a Schizosaccharomyces pombe Tup1p homolog.";
RL   Mol. Cell. Biol. 19:8461-8468(1999).
CC   -!- FUNCTION: Represses transcription by RNA polymerase II.
CC   -!- SIMILARITY: Belongs to the WD repeat TUP1 family. {ECO:0000305}.
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DR   EMBL; AF005740; AAB63194.1; -; Genomic_DNA.
DR   EMBL; CR382126; CAG98255.1; -; Genomic_DNA.
DR   RefSeq; XP_455547.1; XM_455547.1.
DR   AlphaFoldDB; P56094; -.
DR   SMR; P56094; -.
DR   STRING; 28985.XP_455547.1; -.
DR   EnsemblFungi; CAG98255; CAG98255; KLLA0_F10263g.
DR   GeneID; 2895005; -.
DR   KEGG; kla:KLLA0_F10263g; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   HOGENOM; CLU_000288_57_23_1; -.
DR   InParanoid; P56094; -.
DR   OMA; DYYILYN; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR013890; Tscrpt_rep_Tup1_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF08581; Tup_N; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 5.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..682
FT                   /note="General transcriptional corepressor TUP1"
FT                   /id="PRO_0000051309"
FT   REPEAT          319..359
FT                   /note="WD 1"
FT   REPEAT          404..443
FT                   /note="WD 2"
FT   REPEAT          446..485
FT                   /note="WD 3"
FT   REPEAT          487..527
FT                   /note="WD 4"
FT   REPEAT          537..576
FT                   /note="WD 5"
FT   REPEAT          586..625
FT                   /note="WD 6"
FT   REPEAT          628..673
FT                   /note="WD 7"
FT   REGION          97..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..256
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        635
FT                   /note="S -> Y (in Ref. 1; AAB63194)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        670
FT                   /note="S -> G (in Ref. 1; AAB63194)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   682 AA;  74008 MW;  DA119FC373764466 CRC64;
     MSSVAASQNK INDLLEAIRQ EFANVSQEAN SYRLQNQKDY DFKINQQLAE MQQVRNTVYE
     LELTHRKMKD AYEEEISRLK LELEQKDRQL ASIAHGSTVG NVPGQVPQLS RNSGAQGNAN
     IAPPNIPQPM VSQTVGTGMA PQMAPLNTQH PTQQTKSNAG EQAAANLAPV IQQQQQPQQQ
     LPPQQQQQQQ QQQQSNIPVT TAAPVQPAGG NLDQTVPNSI SPQQQPTEQQ QPASTATTAP
     ATASTAPPTS APSDQVGQDH YLVPADQRAV HAKPIPPFLL DLDSQLVPSH LKKQNNDYYV
     LHNPALPTDL DVELHKSLEH SSVVCCVRFS SDGEFLATGC NKTTQVYKVS TGELVARLSD
     DSASQPQPQP QNQTVTAETS TSNSNGSSAE DGTGNQNSAA STASSDLYIR SVCFSPDGKF
     LATGAEDKLI RIWDLETKKI VMTLKGHEQD IYSLDYFPSG NKLVSGSGDR TVRIWDLTTG
     TCSLTLSIED GVTTVAVSPG EGKFIAAGSL DRTVRVWDSD TGFLVERLDS ENELGTGHRD
     SVYSVVFTRD GKGVVSGSLD RSVKLWNLNG LSGQKSHAEC EVTYTGHKDF VLSVATTQND
     EYILSGSKDR GVLFWDTKSG NPLLMLQGHR NSVISVTVAN GHPLGPEYGV FATGSGDCKA
     RIWKYSKKNS QQNSTQIKEI KE