ID   TUPB_CAMJE              Reviewed;         239 AA.
AC   Q0P886;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Tungstate uptake system permease protein TupB {ECO:0000305};
GN   Name=tupB {ECO:0000303|PubMed:19818021};
GN   OrderedLocusNames=Cj1539c {ECO:0000312|EMBL:CAL35639.1};
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
RN   [2]
RP   PROBABLE FUNCTION IN TUNGSTATE UPTAKE.
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=19818021; DOI=10.1111/j.1365-2958.2009.06902.x;
RA   Smart J.P., Cliff M.J., Kelly D.J.;
RT   "A role for tungsten in the biology of Campylobacter jejuni: tungstate
RT   stimulates formate dehydrogenase activity and is transported via an ultra-
RT   high affinity ABC system distinct from the molybdate transporter.";
RL   Mol. Microbiol. 74:742-757(2009).
CC   -!- FUNCTION: Part of an ABC transporter complex involved in ultra-high
CC       affinity tungstate uptake. Probably responsible for the translocation
CC       of the substrate across the membrane. {ECO:0000305|PubMed:19818021}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (TupC),
CC       two transmembrane proteins (TupB) and a solute-binding protein (TupA).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; AL111168; CAL35639.1; -; Genomic_DNA.
DR   PIR; A81301; A81301.
DR   RefSeq; WP_010891942.1; NC_002163.1.
DR   RefSeq; YP_002344911.1; NC_002163.1.
DR   AlphaFoldDB; Q0P886; -.
DR   SMR; Q0P886; -.
DR   STRING; 192222.Cj1539c; -.
DR   TCDB; 3.A.1.6.11; the atp-binding cassette (abc) superfamily.
DR   PaxDb; Q0P886; -.
DR   EnsemblBacteria; CAL35639; CAL35639; Cj1539c.
DR   GeneID; 905821; -.
DR   KEGG; cje:Cj1539c; -.
DR   PATRIC; fig|192222.6.peg.1516; -.
DR   eggNOG; COG4662; Bacteria.
DR   HOGENOM; CLU_016047_14_2_7; -.
DR   OMA; EVGVAMM; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..239
FT                   /note="Tungstate uptake system permease protein TupB"
FT                   /id="PRO_0000435509"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          37..233
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   239 AA;  26419 MW;  9F684BAB4262050D CRC64;
     MLKLLILKRI FLDYIFDGFK QALFLLFNAD ESVISAIKTT LLSSSISIVL ALLIGFPLGF
     ILGFFEFKLK RFIKLIVDTS LSFPTVAVGL ILYALISSRG PLGEFGLLFT IKALILGQFI
     LALPIVIALF SNLIENMNKK HFLLIKSFHL SPLKLVLTMI YELRFALISV VALAYGRIVA
     EVGVAMIVGG NIKYDTRTIT TAISLETNKG EFASGIALAL VLILIAFCLN FITHKLKRT