ID   TUPC_PEPAC              Reviewed;         214 AA.
AC   Q93KD4;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Tungstate uptake system ATP-binding protein TupC {ECO:0000305};
DE            EC=7.3.2.6 {ECO:0000305|PubMed:11292832};
GN   Name=tupC {ECO:0000303|PubMed:11292832};
OS   Peptoclostridium acidaminophilum (Eubacterium acidaminophilum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Peptoclostridium.
OX   NCBI_TaxID=1731;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROBABLE FUNCTION IN TUNGSTATE
RP   UPTAKE.
RC   STRAIN=ATCC 49065 / DSM 3953 / al-2;
RX   PubMed=11292832; DOI=10.1074/jbc.m101293200;
RA   Makdessi K., Andreesen J.R., Pich A.;
RT   "Tungstate uptake by a highly specific ABC transporter in Eubacterium
RT   acidaminophilum.";
RL   J. Biol. Chem. 276:24557-24564(2001).
CC   -!- FUNCTION: Part of an ABC transporter complex involved in tungstate
CC       uptake. Probably responsible for energy coupling to the transport
CC       system. {ECO:0000305|PubMed:11292832}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + tungstate(in) = ADP + H(+) + phosphate +
CC         tungstate(out); Xref=Rhea:RHEA:35027, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46502, ChEBI:CHEBI:456216; EC=7.3.2.6;
CC         Evidence={ECO:0000305|PubMed:11292832};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (TupC),
CC       two transmembrane proteins (TupB) and a solute-binding protein (TupA).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AJ291988; CAC40784.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q93KD4; -.
DR   SMR; Q93KD4; -.
DR   TCDB; 3.A.1.6.2; the atp-binding cassette (abc) superfamily.
DR   GO; GO:1901238; F:ABC-type tungstate transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Nucleotide-binding; Translocase; Transport.
FT   CHAIN           1..214
FT                   /note="Tungstate uptake system ATP-binding protein TupC"
FT                   /id="PRO_0000435512"
FT   DOMAIN          3..214
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         35..42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   214 AA;  23593 MW;  B9BF84F496DE4A71 CRC64;
     MQITVSNLKK SYGGSTVLDV ESLTFESGKI TGIIGPNGAG KTTLLNIISG IDMDFEGDVE
     YSGSDYSEVK RDITMVFQKG GLLKRSVFEN IAYPLKLRGT DKNEIQQTVV ELMRHLGIEE
     LSSKKAHKLS GGETQRVALA RALAIKPRAL LLDEPTASID PEYMETIEKC IVDYNRKSKA
     TILIITHSMD QARRLCDNIV FLESGRVGEA DGFF