TUR8_MOUSE
ID TUR8_MOUSE Reviewed; 224 AA.
AC P19473;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Tumor rejection antigen P815A;
GN Name=Trap1a; Synonyms=P1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=DBA/2J;
RX PubMed=1903428; DOI=10.1084/jem.173.6.1373;
RA van den Eynde B., Lethe B.G., van Pel A., de Plaen E., Boon T.;
RT "The gene coding for a major tumor rejection antigen of tumor P815 is
RT identical to the normal gene of syngeneic DBA/2 mice.";
RL J. Exp. Med. 173:1373-1384(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trophoblast;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: P185A and B result from the expression by tumor
CC P815 of a gene that is silent or expressed at a very low level in most
CC if not all normal cells of adult mice. Expressed in testis and
CC mastocytoma.
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DR EMBL; M36387; AAA40475.1; -; mRNA.
DR EMBL; M36386; AAA40474.1; -; Genomic_DNA.
DR EMBL; BC051644; AAH51644.1; -; mRNA.
DR CCDS; CCDS30433.1; -.
DR PIR; JH0456; JH0456.
DR RefSeq; NP_035765.1; NM_011635.2.
DR AlphaFoldDB; P19473; -.
DR BioGRID; 204310; 1.
DR STRING; 10090.ENSMUSP00000059448; -.
DR iPTMnet; P19473; -.
DR PhosphoSitePlus; P19473; -.
DR PaxDb; P19473; -.
DR PRIDE; P19473; -.
DR ProteomicsDB; 298067; -.
DR DNASU; 22037; -.
DR Ensembl; ENSMUST00000054534; ENSMUSP00000059448; ENSMUSG00000051257.
DR GeneID; 22037; -.
DR KEGG; mmu:22037; -.
DR UCSC; uc009uke.1; mouse.
DR CTD; 22037; -.
DR MGI; MGI:98818; Trap1a.
DR VEuPathDB; HostDB:ENSMUSG00000051257; -.
DR GeneTree; ENSGT00520000059524; -.
DR HOGENOM; CLU_1234673_0_0_1; -.
DR InParanoid; P19473; -.
DR OMA; WIARQSK; -.
DR OrthoDB; 1496005at2759; -.
DR BioGRID-ORCS; 22037; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Trap1a; mouse.
DR PRO; PR:P19473; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; P19473; protein.
DR Bgee; ENSMUSG00000051257; Expressed in placenta labyrinth and 25 other tissues.
DR ExpressionAtlas; P19473; baseline and differential.
DR Genevisible; P19473; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Tumor antigen.
FT CHAIN 1..224
FT /note="Tumor rejection antigen P815A"
FT /id="PRO_0000065697"
FT REGION 76..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 5..9
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 83..133
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..218
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 224 AA; 25758 MW; 57D97598F2CD6ED2 CRC64;
MSDNKKPDKA HSGSGGDGDG NRCNLLHRYS LEEILPYLGW LVFAVVTTSF LALQMFIDAL
YEEQYERDVA WIARQSKRMS SVDEDEDDED DEDDYYDDED DDDDAFYDDE DDEEEELENL
MDDESEDEAE EEMSVEMGAG AEEMGAGANC ACVPGHHLRK NEVKCRMIYF FHDPNFLVSI
PVNPKEQMEC RCENADEEVA MEEEEEEEEE EEEEEMGNPD GFSP
