ID   C555A_DICDI             Reviewed;         484 AA.
AC   Q54LA8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Probable cytochrome P450 555A1;
DE            EC=1.14.-.-;
GN   Name=cyp555A1; ORFNames=DDB_G0286743;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AAFI02000089; EAL64127.1; -; Genomic_DNA.
DR   RefSeq; XP_637653.1; XM_632561.1.
DR   AlphaFoldDB; Q54LA8; -.
DR   SMR; Q54LA8; -.
DR   STRING; 44689.DDB0233048; -.
DR   PaxDb; Q54LA8; -.
DR   EnsemblProtists; EAL64127; EAL64127; DDB_G0286743.
DR   GeneID; 8625793; -.
DR   KEGG; ddi:DDB_G0286743; -.
DR   dictyBase; DDB_G0286743; cyp555A1.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_22_0_1; -.
DR   InParanoid; Q54LA8; -.
DR   OMA; AEPRDFI; -.
DR   PhylomeDB; Q54LA8; -.
DR   Reactome; R-DDI-211935; Fatty acids.
DR   Reactome; R-DDI-211958; Miscellaneous substrates.
DR   Reactome; R-DDI-211981; Xenobiotics.
DR   Reactome; R-DDI-211999; CYP2E1 reactions.
DR   Reactome; R-DDI-2142670; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
DR   Reactome; R-DDI-2142816; Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
DR   Reactome; R-DDI-5423646; Aflatoxin activation and detoxification.
DR   Reactome; R-DDI-9027307; Biosynthesis of maresin-like SPMs.
DR   Reactome; R-DDI-9749641; Aspirin ADME.
DR   Reactome; R-DDI-9753281; Paracetamol ADME.
DR   PRO; PR:Q54LA8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR   GO; GO:0006082; P:organic acid metabolic process; IBA:GO_Central.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..484
FT                   /note="Probable cytochrome P450 555A1"
FT                   /id="PRO_0000318844"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         432
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   484 AA;  56886 MW;  6359287B89172013 CRC64;
     MIIIVIVVFL FYFSFLNLNL NPKKKRPPSP ITLPVIGNLI SLLNNQPQNI LFNYYKKYGK
     IYQLQYGIVN TVVLSEFDIL KEAFIENGEV FIERYNKITK KFKSSENIVN SNGLIWKKLQ
     SISIQELSPN IKIKKYEPMI INETNKLIDS FNEHIKSNES IDPTLNIKIC FLNIIISFLF
     NFRYNDYKDE KVIQLVDYIH SIFRMGSHPI PQDYIPILNK FYINKTTKIH QKIFENIYEY
     IENQVQKRLE ILNKNNNNNN NNINECFVDL LLLKFKSNLL TWNEVIKTTT DLMIAGSDTN
     SLFTIHLIIA LTNRENIQNK VFNEILNFYI LNENNKITFS NKSKTPYYNS VLKEVERRFT
     VSPLSQPHRT NKDIILNGYF IPSGSQIIQN VYSCHLNDKD WENPFQFNPD RFLNNNQLEK
     KLITFGMGPR NCLGFQFALM SIWIVNLILF KSIKFSSNKL IEEEIREGGT TLSPFPFKIN
     LIKR