ID   C556A_DICDI             Reviewed;         657 AA.
AC   Q54PT3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Probable cytochrome P450 556A1;
DE            EC=1.14.-.-;
GN   Name=cyp556A1; ORFNames=DDB_G0284345;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AAFI02000064; EAL65221.1; -; Genomic_DNA.
DR   RefSeq; XP_638571.1; XM_633479.1.
DR   AlphaFoldDB; Q54PT3; -.
DR   SMR; Q54PT3; -.
DR   STRING; 44689.DDB0233049; -.
DR   PaxDb; Q54PT3; -.
DR   EnsemblProtists; EAL65221; EAL65221; DDB_G0284345.
DR   GeneID; 8624543; -.
DR   KEGG; ddi:DDB_G0284345; -.
DR   dictyBase; DDB_G0284345; cyp556A1.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_417648_0_0_1; -.
DR   InParanoid; Q54PT3; -.
DR   OMA; WYPIVEI; -.
DR   PhylomeDB; Q54PT3; -.
DR   PRO; PR:Q54PT3; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   SUPFAM; SSF48264; SSF48264; 2.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..657
FT                   /note="Probable cytochrome P450 556A1"
FT                   /id="PRO_0000318845"
FT   TRANSMEM        2..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          440..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         587
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   657 AA;  76315 MW;  8450D8D49A76B961 CRC64;
     MFLTSILYTI IIILIFYKGL EYLIEKRSFP LVHPIKGVMN GTKPYFIFGD LPFQRLLNLK
     PKLKELGSIY FRWFFWYPIV EIKDINAIQY VYNEKSNNYS LYWNLNKSSN FILTGSEIKR
     FFRIYYCAFN CKDSLQRIMP VIKSQVFDFI HSHKFQNSTL STNDDVTNFM LKLLSRVYLG
     SSDEAYHCFK ANYKKFNKSY LDFFHYLFPT LLKIPSKFSR KYIKNKNKRA LYQVLAMKAY
     YGVVKQSSDD HIEESMINII AETSYNDKEG LSLEEIKMPS YLLNASSIKG PMIMVENLMF
     QLIEKSEIES KIRKEIKLVF EKNGKDVNSF DFDDIMEMKY LEATLDEINR LYPPFPKLMP
     RQTKESDRIL GYHIPKGTMI SCPVADILRD PSNFQDPLTF KPERQLIFSN PKFASPSITS
     IQEINGLSSS SSNSFALHHR SLPSINNNNN NNNNNNNNNN NNNNNNNNNN SNNNSINGNN
     KNNNRNCIQS FNNSALKKSF LSDSSSIIDN IVGTNRVDKL KLDSLNENSN INNNNNKDLL
     NVPNIIEINK NNPISNNKYN SYNNLTIEER NQRIIKNLPW GIGSKKCLGK ELAKLIVKTI
     IVILYSQYTF DKHLDENDEE LCDTNNQPKI QITFNPEIKP PLLLKSRKLF SISQPKQ