TUSB_SALTI
ID TUSB_SALTI Reviewed; 95 AA.
AC Q8Z1Y1; Q7C5R0;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Protein TusB {ECO:0000255|HAMAP-Rule:MF_01564};
DE AltName: Full=tRNA 2-thiouridine synthesizing protein B {ECO:0000255|HAMAP-Rule:MF_01564};
GN Name=tusB {ECO:0000255|HAMAP-Rule:MF_01564};
GN OrderedLocusNames=STY4349, t4056;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Part of a sulfur-relay system required for 2-thiolation of 5-
CC methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
CC {ECO:0000255|HAMAP-Rule:MF_01564}.
CC -!- SUBUNIT: Heterohexamer, formed by a dimer of trimers. The hexameric
CC TusBCD complex contains 2 copies each of TusB, TusC and TusD. The
CC TusBCD complex interacts with TusE. {ECO:0000255|HAMAP-Rule:MF_01564}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01564}.
CC -!- SIMILARITY: Belongs to the DsrH/TusB family. {ECO:0000255|HAMAP-
CC Rule:MF_01564}.
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DR EMBL; AL513382; CAD08164.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO71523.1; -; Genomic_DNA.
DR RefSeq; NP_458451.1; NC_003198.1.
DR RefSeq; WP_000903398.1; NZ_WSUR01000001.1.
DR AlphaFoldDB; Q8Z1Y1; -.
DR SMR; Q8Z1Y1; -.
DR STRING; 220341.16505140; -.
DR EnsemblBacteria; AAO71523; AAO71523; t4056.
DR KEGG; stt:t4056; -.
DR KEGG; sty:STY4349; -.
DR PATRIC; fig|220341.7.peg.4444; -.
DR eggNOG; COG2168; Bacteria.
DR HOGENOM; CLU_166087_2_1_6; -.
DR OMA; MLHTINK; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002143; P:tRNA wobble position uridine thiolation; IEA:InterPro.
DR Gene3D; 3.40.1260.10; -; 1.
DR HAMAP; MF_01564; Thiourid_synth_B; 1.
DR InterPro; IPR027396; DsrEFH-like.
DR InterPro; IPR023526; Sulphur_relay_TusB.
DR InterPro; IPR007215; Sulphur_relay_TusB/DsrH.
DR PANTHER; PTHR37526; PTHR37526; 1.
DR Pfam; PF04077; DsrH; 1.
DR SUPFAM; SSF75169; SSF75169; 1.
DR TIGRFAMs; TIGR03011; sulf_tusB_dsrH; 1.
PE 3: Inferred from homology;
KW Cytoplasm; tRNA processing.
FT CHAIN 1..95
FT /note="Protein TusB"
FT /id="PRO_0000234518"
SQ SEQUENCE 95 AA; 10502 MW; E05B0F6C7E41D148 CRC64;
MLHTLPHCAS GVDFPALLRL LKEGDALLLL QDGVTVAIEG NRFLESLRDA PITVYALKED
IDARGLGGQI SDSVVRVDYT EFVRLTVKYA NQMAW
