TUSC1_HUMAN
ID TUSC1_HUMAN Reviewed; 212 AA.
AC Q2TAM9; A0PJ78; Q67GI3; Q86SS1; Q8TAH8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Tumor suppressor candidate gene 1 protein;
DE AltName: Full=TSG-9;
DE Short=TSG9;
GN Name=TUSC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15208665; DOI=10.1038/sj.onc.1207857;
RA Shan Z., Parker T., Wiest J.S.;
RT "Identifying novel homozygous deletions by microsatellite analysis and
RT characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome
RT 9p in human lung cancer.";
RL Oncogene 23:6612-6620(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-123.
RC TISSUE=Brain, Colon, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] ASP-123, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- TISSUE SPECIFICITY: Widely expressed at low level. Expressed at higher
CC level in testis, weakly expressed in muscle, colon, lung and spleen.
CC Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with
CC homozygous deletion of the 9p region, while it is down-regulated in 3
CC other tumor cell lines. {ECO:0000269|PubMed:15208665}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO38227.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY168647; AAO38227.2; ALT_INIT; mRNA.
DR EMBL; AL590322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017510; AAH17510.1; -; mRNA.
DR EMBL; BC028316; AAH28316.1; -; mRNA.
DR EMBL; BC046919; AAH46919.1; -; mRNA.
DR EMBL; BC110824; AAI10825.1; -; mRNA.
DR RefSeq; NP_001004125.1; NM_001004125.2.
DR AlphaFoldDB; Q2TAM9; -.
DR SMR; Q2TAM9; -.
DR BioGRID; 130351; 7.
DR IntAct; Q2TAM9; 3.
DR MINT; Q2TAM9; -.
DR STRING; 9606.ENSP00000350716; -.
DR iPTMnet; Q2TAM9; -.
DR PhosphoSitePlus; Q2TAM9; -.
DR BioMuta; TUSC1; -.
DR DMDM; 259016374; -.
DR EPD; Q2TAM9; -.
DR jPOST; Q2TAM9; -.
DR MassIVE; Q2TAM9; -.
DR MaxQB; Q2TAM9; -.
DR PaxDb; Q2TAM9; -.
DR PeptideAtlas; Q2TAM9; -.
DR PRIDE; Q2TAM9; -.
DR ProteomicsDB; 61470; -.
DR Antibodypedia; 24938; 123 antibodies from 20 providers.
DR DNASU; 286319; -.
DR Ensembl; ENST00000358022.6; ENSP00000350716.4; ENSG00000198680.6.
DR GeneID; 286319; -.
DR KEGG; hsa:286319; -.
DR UCSC; uc003zpx.4; human.
DR CTD; 286319; -.
DR DisGeNET; 286319; -.
DR GeneCards; TUSC1; -.
DR HGNC; HGNC:31010; TUSC1.
DR HPA; ENSG00000198680; Low tissue specificity.
DR MIM; 610529; gene.
DR neXtProt; NX_Q2TAM9; -.
DR PharmGKB; PA134889281; -.
DR VEuPathDB; HostDB:ENSG00000198680; -.
DR eggNOG; ENOG502SVWC; Eukaryota.
DR HOGENOM; CLU_113559_0_0_1; -.
DR InParanoid; Q2TAM9; -.
DR OMA; MGPMWRM; -.
DR OrthoDB; 1386758at2759; -.
DR PhylomeDB; Q2TAM9; -.
DR TreeFam; TF336220; -.
DR PathwayCommons; Q2TAM9; -.
DR SignaLink; Q2TAM9; -.
DR BioGRID-ORCS; 286319; 5 hits in 1056 CRISPR screens.
DR GenomeRNAi; 286319; -.
DR Pharos; Q2TAM9; Tbio.
DR PRO; PR:Q2TAM9; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q2TAM9; protein.
DR Bgee; ENSG00000198680; Expressed in epithelial cell of pancreas and 193 other tissues.
DR Genevisible; Q2TAM9; HS.
DR InterPro; IPR043450; CCDC89-like.
DR PANTHER; PTHR34768; PTHR34768; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..212
FT /note="Tumor suppressor candidate gene 1 protein"
FT /id="PRO_0000312284"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 73..117
FT /evidence="ECO:0000255"
FT COILED 155..180
FT /evidence="ECO:0000255"
FT COMPBIAS 133..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 153
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983"
FT VARIANT 123
FT /note="N -> D (in dbSNP:rs34498078)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0007744|PubMed:21269460"
FT /id="VAR_037471"
SQ SEQUENCE 212 AA; 23390 MW; 8D7B0038B40AA9B4 CRC64;
MGPMWRMRGG ATRRGSCCGG DGAADGRGPG RSGRARGGGS PSGGGGGVGW RGRADGARQQ
LEERFADLAA SHLEAIRARD EWDRQNARLR QENARLRLEN RRLKRENRSL FRQALRLPGE
GGNGTPAEAR RVPEEASTNR RARDSGREDE PGSPRALRAR LEKLEAMYRR ALLQLHLEQR
GPRPSGDKEE QPLQEPDSGL RSRDSEPSGP WL
