TUSC1_MOUSE
ID TUSC1_MOUSE Reviewed; 205 AA.
AC Q673H1; Q9CVE2;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Tumor suppressor candidate gene 1 protein homolog;
GN Name=Tusc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15208665; DOI=10.1038/sj.onc.1207857;
RA Shan Z., Parker T., Wiest J.S.;
RT "Identifying novel homozygous deletions by microsatellite analysis and
RT characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome
RT 9p in human lung cancer.";
RL Oncogene 23:6612-6620(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-205.
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AY546089; AAT10387.1; -; mRNA.
DR EMBL; AL928673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK008612; BAB25777.1; -; mRNA.
DR CCDS; CCDS18357.1; -.
DR RefSeq; NP_081230.1; NM_026954.1.
DR AlphaFoldDB; Q673H1; -.
DR SMR; Q673H1; -.
DR BioGRID; 213250; 1.
DR STRING; 10090.ENSMUSP00000069652; -.
DR iPTMnet; Q673H1; -.
DR PhosphoSitePlus; Q673H1; -.
DR EPD; Q673H1; -.
DR MaxQB; Q673H1; -.
DR PaxDb; Q673H1; -.
DR PeptideAtlas; Q673H1; -.
DR PRIDE; Q673H1; -.
DR ProteomicsDB; 298385; -.
DR Antibodypedia; 24938; 123 antibodies from 20 providers.
DR Ensembl; ENSMUST00000066774; ENSMUSP00000069652; ENSMUSG00000054000.
DR GeneID; 69136; -.
DR KEGG; mmu:69136; -.
DR UCSC; uc008tou.1; mouse.
DR CTD; 286319; -.
DR MGI; MGI:2684283; Tusc1.
DR VEuPathDB; HostDB:ENSMUSG00000054000; -.
DR eggNOG; ENOG502SVWC; Eukaryota.
DR GeneTree; ENSGT00390000013920; -.
DR HOGENOM; CLU_113559_0_0_1; -.
DR InParanoid; Q673H1; -.
DR OMA; MGPMWRM; -.
DR OrthoDB; 1461686at2759; -.
DR PhylomeDB; Q673H1; -.
DR TreeFam; TF336220; -.
DR BioGRID-ORCS; 69136; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q673H1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q673H1; protein.
DR Bgee; ENSMUSG00000054000; Expressed in humerus cartilage element and 210 other tissues.
DR Genevisible; Q673H1; MM.
DR InterPro; IPR043450; CCDC89-like.
DR PANTHER; PTHR34768; PTHR34768; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..205
FT /note="Tumor suppressor candidate gene 1 protein homolog"
FT /id="PRO_0000312285"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..110
FT /evidence="ECO:0000255"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2TAM9"
SQ SEQUENCE 205 AA; 22712 MW; EA2B0264A7300803 CRC64;
MWRMRGGATR RGSCGGEGGG SRGESGRLGR AREGGGGGGG VGWRGRAGGA RRQLEERFAD
LAASHLEALR ARDERDRQNA RLREENARLR LENRRLRREN RSLFRQALRL PGDSGEREAA
VETLAPDEPA TNRKARGHGR EEEPGSPRAL RARLEKLEVM YRRALLQLHL EQQGARPPGA
IEEPPLQETA TGLCAHDPDV PRPWL