TUSC2_MOUSE
ID TUSC2_MOUSE Reviewed; 110 AA.
AC Q9WVF8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Tumor suppressor candidate 2;
DE AltName: Full=Fusion 1 protein;
DE Short=Fus-1 protein;
DE AltName: Full=PDGFA-associated protein 2;
GN Name=Tusc2; Synonyms=Fus1, Lgcc, Pdap2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Duh F.-M., Minna J.D., Lerman M.I.;
RT "Mouse ortholog of the human Fus1 gene.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- PTM: Myristoylation is required for tumor suppressor activity.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TUSC2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF123387; AAD42286.1; -; mRNA.
DR EMBL; BC048477; AAH48477.1; -; mRNA.
DR CCDS; CCDS23495.1; -.
DR RefSeq; NP_062716.1; NM_019742.4.
DR AlphaFoldDB; Q9WVF8; -.
DR STRING; 10090.ENSMUSP00000010198; -.
DR iPTMnet; Q9WVF8; -.
DR PhosphoSitePlus; Q9WVF8; -.
DR MaxQB; Q9WVF8; -.
DR PaxDb; Q9WVF8; -.
DR PRIDE; Q9WVF8; -.
DR ProteomicsDB; 298030; -.
DR Antibodypedia; 30895; 202 antibodies from 30 providers.
DR DNASU; 80385; -.
DR Ensembl; ENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054.
DR GeneID; 80385; -.
DR KEGG; mmu:80385; -.
DR UCSC; uc009rls.1; mouse.
DR CTD; 11334; -.
DR MGI; MGI:1931086; Tusc2.
DR VEuPathDB; HostDB:ENSMUSG00000010054; -.
DR eggNOG; ENOG502S21H; Eukaryota.
DR GeneTree; ENSGT00390000008040; -.
DR HOGENOM; CLU_152285_0_0_1; -.
DR InParanoid; Q9WVF8; -.
DR OMA; WPFSAPA; -.
DR OrthoDB; 1596343at2759; -.
DR PhylomeDB; Q9WVF8; -.
DR TreeFam; TF314634; -.
DR BioGRID-ORCS; 80385; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Tusc2; mouse.
DR PRO; PR:Q9WVF8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9WVF8; protein.
DR Bgee; ENSMUSG00000010054; Expressed in right kidney and 230 other tissues.
DR ExpressionAtlas; Q9WVF8; baseline and differential.
DR Genevisible; Q9WVF8; MM.
DR GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR GO; GO:0048469; P:cell maturation; IMP:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:MGI.
DR GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR GO; GO:0001779; P:natural killer cell differentiation; IMP:MGI.
DR GO; GO:0032700; P:negative regulation of interleukin-17 production; IMP:MGI.
DR GO; GO:0070945; P:neutrophil-mediated killing of gram-negative bacterium; IMP:MGI.
DR GO; GO:0006909; P:phagocytosis; IMP:MGI.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IMP:MGI.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; IMP:MGI.
DR GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:MGI.
DR InterPro; IPR029393; FUS1.
DR PANTHER; PTHR15453; PTHR15453; 1.
DR Pfam; PF15000; TUSC2; 1.
PE 1: Evidence at protein level;
KW Lipoprotein; Myristate; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O75896"
FT CHAIN 2..110
FT /note="Tumor suppressor candidate 2"
FT /id="PRO_0000148171"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 110 AA; 12136 MW; 310698A5CB12DC40 CRC64;
MGASGSKARG LWPFASTPGG GGPEAAGSEQ SLVRSRARAV PPFVFTRRGS MFYDEDGDLA
HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDPPRIH VDFPVILYEV
