TUSC_BUCAP
ID TUSC_BUCAP Reviewed; 119 AA.
AC Q8K945;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein TusC {ECO:0000255|HAMAP-Rule:MF_00389};
DE AltName: Full=tRNA 2-thiouridine synthesizing protein C {ECO:0000255|HAMAP-Rule:MF_00389};
GN Name=tusC {ECO:0000255|HAMAP-Rule:MF_00389}; OrderedLocusNames=BUsg_512;
OS Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=198804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sg;
RX PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
CC -!- FUNCTION: Part of a sulfur-relay system required for 2-thiolation of 5-
CC methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
CC {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SUBUNIT: Heterohexamer, formed by a dimer of trimers. The hexameric
CC TusBCD complex contains 2 copies each of TusB, TusC and TusD. The
CC TusBCD complex interacts with TusE. {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SIMILARITY: Belongs to the DsrF/TusC family. {ECO:0000255|HAMAP-
CC Rule:MF_00389}.
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DR EMBL; AE013218; AAM68055.1; -; Genomic_DNA.
DR RefSeq; WP_044006062.1; NC_004061.1.
DR AlphaFoldDB; Q8K945; -.
DR SMR; Q8K945; -.
DR STRING; 198804.BUsg_512; -.
DR EnsemblBacteria; AAM68055; AAM68055; BUsg_512.
DR KEGG; bas:BUsg_512; -.
DR eggNOG; COG2923; Bacteria.
DR HOGENOM; CLU_155943_1_0_6; -.
DR OMA; LEMILIM; -.
DR OrthoDB; 1768076at2; -.
DR Proteomes; UP000000416; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1260.10; -; 1.
DR HAMAP; MF_00389; Thiourid_synth_C; 1.
DR InterPro; IPR027396; DsrEFH-like.
DR InterPro; IPR003787; Sulphur_relay_DsrE/F-like.
DR InterPro; IPR037450; Sulphur_relay_TusC.
DR InterPro; IPR017462; Sulphur_relay_TusC/DsrF.
DR PANTHER; PTHR38780; PTHR38780; 1.
DR Pfam; PF02635; DrsE; 1.
DR SUPFAM; SSF75169; SSF75169; 1.
DR TIGRFAMs; TIGR03010; sulf_tusC_dsrF; 1.
PE 3: Inferred from homology;
KW Cytoplasm; tRNA processing.
FT CHAIN 1..119
FT /note="Protein TusC"
FT /id="PRO_0000214881"
SQ SEQUENCE 119 AA; 13610 MW; 6EE924AD44058CC0 CRC64;
MEKIAFVFSH APHGTSFGKE GLDVILGVSS IIKKISLFFI GDGVLQILKH SKSENILARN
YTSSFRILSI YDIKNFYCCK SSLIDRGLYS HNQFILKVNI LNSYFFRIKL DDHDAIINF