TUSC_BUCAT
ID TUSC_BUCAT Reviewed; 119 AA.
AC B8D856;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Protein TusC {ECO:0000255|HAMAP-Rule:MF_00389};
DE AltName: Full=tRNA 2-thiouridine synthesizing protein C {ECO:0000255|HAMAP-Rule:MF_00389};
GN Name=tusC {ECO:0000255|HAMAP-Rule:MF_00389};
GN OrderedLocusNames=BUAPTUC7_525;
OS Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=561501;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuc7;
RX PubMed=19150844; DOI=10.1126/science.1167140;
RA Moran N.A., McLaughlin H.J., Sorek R.;
RT "The dynamics and time scale of ongoing genomic erosion in symbiotic
RT bacteria.";
RL Science 323:379-382(2009).
CC -!- FUNCTION: Part of a sulfur-relay system required for 2-thiolation of 5-
CC methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
CC {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SUBUNIT: Heterohexamer, formed by a dimer of trimers. The hexameric
CC TusBCD complex contains 2 copies each of TusB, TusC and TusD. The
CC TusBCD complex interacts with TusE. {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SIMILARITY: Belongs to the DsrF/TusC family. {ECO:0000255|HAMAP-
CC Rule:MF_00389}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001158; ACL30321.1; -; Genomic_DNA.
DR RefSeq; WP_010896150.1; NC_011834.1.
DR AlphaFoldDB; B8D856; -.
DR SMR; B8D856; -.
DR KEGG; bau:BUAPTUC7_525; -.
DR HOGENOM; CLU_155943_1_0_6; -.
DR OMA; LEMILIM; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1260.10; -; 1.
DR HAMAP; MF_00389; Thiourid_synth_C; 1.
DR InterPro; IPR027396; DsrEFH-like.
DR InterPro; IPR003787; Sulphur_relay_DsrE/F-like.
DR InterPro; IPR037450; Sulphur_relay_TusC.
DR InterPro; IPR017462; Sulphur_relay_TusC/DsrF.
DR PANTHER; PTHR38780; PTHR38780; 1.
DR Pfam; PF02635; DrsE; 1.
DR SUPFAM; SSF75169; SSF75169; 1.
DR TIGRFAMs; TIGR03010; sulf_tusC_dsrF; 1.
PE 3: Inferred from homology;
KW Cytoplasm; tRNA processing.
FT CHAIN 1..119
FT /note="Protein TusC"
FT /id="PRO_1000134407"
SQ SEQUENCE 119 AA; 13507 MW; C595F1215BE10938 CRC64;
MKMVAFVFSH APHGISLGRE GLDAIFSISS IFKKISVFFI GDGVLQLIKN QQPEHILARN
YTSSFSILSL YNIKDLYCCK ASLLERGLNN NNNFILNIDV LDSYNLRLKL DNYDAIINF